Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …

Haematological malignancies were previously thought to be driven solely by genetic or
epigenetic lesions within haematopoietic cells. However, the niches that maintain and …

Steady-state hematopoietic stem cells'(HSCs) self-renewal and differentiation toward their
mature progeny in the adult bone marrow is tightly regulated by cues from the …

Like normal hematopoietic stem cells, leukemic stem cells depend on their bone marrow
(BM) microenvironment for survival, but the underlying mechanisms remain largely …

The bone marrow niche has mystified scientists for many years, leading to widespread
investigation to shed light into its molecular and cellular composition. Considerable efforts …

Mesenchymal stromal cells (MSCs) are heterogeneous and primitive cells discovered first in
the bone marrow (BM). They have putative roles in maintaining tissue homeostasis and are …

Critical-sized bone defects often lead to non-union and full-thickness defects of the
calvarium specifically still present reconstructive challenges. In this study, we show that …

Myeloproliferative neoplasms (MPNs) are diseases caused by mutations in the
haematopoietic stem cell (HSC) compartment. Most MPN patients have a common acquired …

Mesenchymal stem cells are culture-derived mesodermal progenitors isolatable from all
vascularized tissues. In spite of multiple fundamental, pre-clinical and clinical studies, the …

Mesenchymal stem cells (MSCs) and osteolineage cells contribute to the hematopoietic
stem cell (HSC) niche in the bone marrow of long bones. However, their developmental …