In eukaryotes, the core promoter serves as a platform for the assembly of transcription
preinitiation complex (PIC) that includes TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA …

Poly (ADP-ribose)(PAR) and the PAR polymerases (PARPs) that catalyze its synthesis from
donor nicotinamide adenine dinucleotide (NAD+) molecules have received considerable …

Poly-ADP-ribose metabolism plays a mayor role in a wide range of biological processes,
such as maintenance of genomic stability, transcriptional regulation, energy metabolism and …

PARP-1, an enzyme that catalyzes the attachment of ADP ribose units to target proteins,
plays at least two important roles in transcription regulation. First, PARP-1 modifies histones …

Mammalian poly (ADP-ribose) polymerase 1 (PARP-1) is an abundant nuclear chromatin-
associated protein and belongs to a large family of enzymes that catalyzes the transfer of …

One of the immediate eukaryotic cellular responses to DNA breakage is the covalent post‐
translational modification of nuclear proteins with poly (ADP‐ribose) from NAD+ as …

Poly (ADP-ribose) polymerase 1 (PARP-1)-deficient mice are protected against septic shock,
diabetes type I, stroke, and inflammation. We report that primary cells from PARP-1 …

H2A. Bbd is an unusual histone variant whose sequence is only 48% conserved compared
to major H2A. The major sequence differences are in the docking domain that tethers the …

We show that PARP-1 is indispensable to retinoic acid receptor (RAR)-mediated
transcription from the RARβ2 promoter in a highly purified, reconstituted transcription system …

Poly (ADP-ribosyl) ation is an immediate cellular response to DNA damage generated either
exogenously or endogenously. This post-translational modification is catalyzed by poly …