The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

The mammalian genome encodes 28 distinct members of the transient receptor potential
(TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for …

Endothelial cells in resistance arteries, arterioles, and capillaries express a diverse array of
ion channels that contribute to Cell-Cell communication in the microcirculation. Endothelial …

The transient receptor potential (TRP) superfamily consists of a large number of
nonselective cation channels with variable degree of Ca2+-permeability. The 28 mammalian …

Upon stimulation with agonists and shear stress, the vascular endothelium of different
vessels selectively releases several vasodilator factors such as nitric oxide and prostacyclin …

Background: Neurovascular coupling (NVC) is the mechanism whereby an increase in
neuronal activity (NA) leads to local elevation in cerebral blood flow (CBF) to match the …

It has become increasingly clear that the accumulation of proteins in specific regions of the
plasma membrane can facilitate cellular communication. These regions, termed signaling …

The vascular endothelium is a broadly distributed and highly specialized organ. The
endothelium has a number of functions including the control of blood vessels diameter …

The endothelium controls vascular tone not only by releasing various vasoactive substances
but also by another pathway associated with the hyperpolarization of both endothelial and …

Small arteries in the body control vascular resistance, and therefore, blood pressure and
blood flow. Endothelial and smooth muscle cells in the arterial walls respond to various …