The paradoxical roles of orphan nuclear receptor 4A (NR4A) in cancer

S Safe, K Karki - Molecular Cancer Research, 2021 - AACR
The three-orphan nuclear receptor 4A genes are induced by diverse stressors and stimuli,
and there is increasing evidence that NR4A1 (Nur77), NR4A2 (Nurr1), and NR4A3 (Nor1) …

High-grade transformation/dedifferentiation in salivary gland carcinomas: occurrence across subtypes and clinical significance

A Skalova, I Leivo, H Hellquist, A Agaimy… - Advances in anatomic …, 2021 - journals.lww.com
High-grade transformation (HGT) or dedifferentiation has been described in a variety of
salivary gland carcinomas, including acinic cell carcinoma, secretory carcinoma, adenoid …

Targeted therapy, chemotherapy, immunotherapy and novel treatment options for different subtypes of salivary gland cancer

SK Mueller, M Haderlein, S Lettmaier… - Journal of Clinical …, 2022 - mdpi.com
Surgical resection remains the first line treatment for salivary gland cancer (SGC). In the
case of locally advanced disease, surgery is followed by adjuvant radiotherapy. Surgical …

An overview on the histogenesis and morphogenesis of salivary gland neoplasms and evolving diagnostic approaches

J Iyer, A Hariharan, UMN Cao, CTT Mai, A Wang… - Cancers, 2021 - mdpi.com
Simple Summary Diagnosing salivary gland neoplasms (SGN) remain a challenge, given
their underlying biological nature and overlapping features. Evolving techniques in …

Molecular pathology of salivary gland neoplasms: diagnostic, prognostic, and predictive perspective

MH Toper, S Sarioglu - Advances in anatomic pathology, 2021 - journals.lww.com
Salivary gland neoplasms are an uncommon and widely heterogeneous group of tumors. In
recent years, there has been considerable progress in efforts to reveal the molecular …

Evaluation of NR4A3 immunohistochemistry (IHC) and fluorescence in situ hybridization and comparison with DOG1 IHC for FNA diagnosis of acinic cell carcinoma

JM Skaugen, RR Seethala, SI Chiosea… - Cancer …, 2021 - Wiley Online Library
Background Acinic cell carcinoma (AcCC) is diagnostically challenging on fine‐needle
aspiration because it can mimic several other neoplasms or even normal acinar tissue …

[HTML][HTML] SalvGlandDx–a comprehensive salivary gland neoplasm specific next generation sequencing panel to facilitate diagnosis and identify therapeutic targets

SN Freiberger, M Brada, C Fritz, S Höller, A Vogetseder… - Neoplasia, 2021 - Elsevier
Diagnosis of salivary gland neoplasms is often challenging due to their high morphological
diversity and overlaps. Several recurrent molecular alterations have been described …

NR4A3 immunohistochemistry reliably discriminates acinic cell carcinoma from mimics

KS Wong, A Mariño-Enriquez, JL Hornick… - Head and Neck …, 2021 - Springer
Acinic cell carcinoma (AciCC) harbors a recurrent t (4; 9)(q13; q31) translocation, which
leads to upregulation of Nuclear Receptor Subfamily 4 Group A Member 3 (NR4A3) …

[HTML][HTML] Acinic cell carcinoma of the breast: a comprehensive review

A Ajkunic, F Skenderi, N Shaker, S Akhtar, J Lamovec… - The Breast, 2022 - Elsevier
Acinic cell carcinoma of the breast is a rare special subtype of breast cancer in the category
of salivary gland-type tumors. It is morphologically similar to acinic cell carcinomas of …

Head and neck acinic cell carcinoma: a new grading system proposal and diagnostic utility of NR4A3 immunohistochemistry

B Xu, M Saliba, A Ho, K Viswanathan… - The American journal …, 2022 - journals.lww.com
Acinic cell carcinoma (AciCC) is traditionally considered as a low-grade salivary gland
carcinoma. However, a subset demonstrates high-grade features with a higher mortality rate …