Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

We present a consolidated view of the complexity and challenges of designing studies for
measurement of energy metabolism in mouse models, including a practical guide to the …

Adipose tissue plays a central role in regulating whole-body energy and glucose
homeostasis through its subtle functions at both organ and systemic levels. On one hand …

Perturbations in metabolic processes are associated with diseases such as obesity, type 2
diabetes mellitus, certain infections and some cancers. A resurgence of interest in creatine …

Summary That uncoupling protein 1 (UCP1) is the sole mediator of adipocyte thermogenesis
is a conventional viewpoint that has primarily been inferred from the attenuation of the …

Leptin has emerged over the past 2 decades as a key hormone secreted by adipose tissue
that conveys information on energy stores. Leptin is considered an important regulator of …

The master transcription factor Pparγ regulates the general differentiation program of both
brown and white adipocytes. However, it has been unclear whether Pparγ also controls fat …

Obesity results from energy imbalance, when energy intake exceeds energy expenditure.
Brown adipose tissue (BAT) drives non-shivering thermogenesis which represents a …

Apart from UCP1-based nonshivering thermogenesis in brown adipocytes, the identity of
thermogenic mechanisms that can be activated to reduce a positive energy balance is …

Background Brown adipose tissue (BAT) is a site of metabolic thermogenesis mediated by
mitochondrial uncoupling protein 1 (UCP1) and represents a target for a therapeutic …