The human T-cell leukemia virus type 1 (HTLV-1), identified as the first human oncogenic
retrovirus 30 years ago, is not an ubiquitous virus. HTLV-1 is present throughout the world …

PML nuclear bodies are nucleated by the PML protein, which polymerizes into spherical
shells where it concentrates many unrelated partner proteins. Emerging data has connected …

Purpose Adult T-cell leukemia-lymphoma (ATL) is a distinct mature T-cell malignancy
caused by chronic infection with human T-lymphotropic virus type 1 with diverse clinical …

The concept of differentiation therapy emerged from the fact that hormones or cytokines may
promote differentiation ex vivo, thereby irreversibly changing the phenotype of cancer cells …

Adult T-cell leukaemia-lymphoma (ATL) is a malignancy of peripheral T lymphocytes caused
by human T-lymphotropic virus type I (HTLV-1), and its prognosis is poor. There are an …

Recent clinical trials have demonstrated that the immense majority of acute promyelocytic
leukemia (APL) patients can be definitively cured by the combination of two targeted …

Human T-cell leukemia virus type 1 (HTLV-1), the first human retrovirus to be discovered, is
present in diverse regions of the world, where its infection is usually neglected in health care …

The fusion oncogene, promyelocytic leukaemia (PML)–retinoic acid receptor-α (RARA),
initiates acute promyelocytic leukaemia (APL) through both a block to differentiation and …

In industrialized countries, cancer is the second leading cause of death after cardiovascular
disease. Most cancer patients die because of metastases, which consist of the self …

Adult T-cell leukemia (ATL) is an aggressive T-cell malignancy caused by human T-cell
leukemia virus type 1 (HTLV-1) that develops through a multistep carcinogenesis process …