In this review, we discuss the importance of capsaicin to the current understanding of
neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We …

The capsaicin (vanilloid) receptor, TRPV1, is a heat-activated cation channel modulated by
inflammatory mediators and contributes to acute and chronic pain. TRPV1 channel is one of …

Despite intense investigation, the mechanisms of the different forms of trigeminal
neuropathic pain remain substantially unidentified. The transient receptor potential ankyrin 1 …

Chemotherapy-induced peripheral neuropathy (CIPN) is a severe and painful adverse
reaction of cancer treatment in patients that is little understood or treated. Cytotoxic drugs …

Spicy food does not only provide an important hedonic input in daily life, but has also been
anedoctically associated to beneficial effects on our health. In this context, the discovery of …

Abstract α‐Spinasterol is a phytosterol found in various edible and non‐edible plant
sources. The edible plant materials containing α‐spinasterol include spinach leaves …

Prunella is a genus of perennial herbaceous plants in the Labiatae family. There are
approximately 15 species worldwide, distributed widely in the temperate regions and …

Ethnopharmacological relevance Petiveria alliacea L. commonly grows in the tropical
regions of the Americas such as the Amazon forest, Central America, Caribbean islands and …

The extraction of plant constituents is essential to isolate biologically active compounds,
aimed to understand their role on the treatment of diabetes. This study was designed to …

To date, 28 mammalian transient receptor potential (TRP) channels have been cloned and
characterized. They are grouped into six subfamilies on the basis of their amino acid …