11β-HSD As a new target in pharmacotherapy of metabolic diseases
D Kupczyk, R Bilski, M Kozakiewicz… - International journal of …, 2022 - mdpi.com
Glucocorticoids (GCs), which are secreted by the adrenal cortex, are important regulators in
the metabolism of carbohydrates, lipids, and proteins. For the proper functioning of the body …
the metabolism of carbohydrates, lipids, and proteins. For the proper functioning of the body …
11β-Hydroxysteroid Dehydrogenase Type 1 as a Potential Treatment Target in Cardiovascular Diseases
D Kupczyk, R Studzińska, R Kołodziejska… - Journal of Clinical …, 2022 - mdpi.com
Glucocorticoids (GCs) belong to the group of steroid hormones. Their representative in
humans is cortisol. GCs are involved in most physiological processes of the body and play a …
humans is cortisol. GCs are involved in most physiological processes of the body and play a …
Synthesis of Novel 2-(Cyclopentylamino)thiazol-4(5H)-one Derivatives with Potential Anticancer, Antioxidant, and 11β-HSD Inhibitory Activities
S Baumgart, D Kupczyk, A Archała, O Koszła… - International Journal of …, 2023 - mdpi.com
In this study, a series of nine new 2-(cyclopentylamino) thiazol-4 (5 H)-one derivatives were
synthesized, and their anticancer, antioxidant, and 11β-hydroxysteroid dehydrogenase (11β …
synthesized, and their anticancer, antioxidant, and 11β-hydroxysteroid dehydrogenase (11β …
Lipophilic Studies and In Silico ADME Profiling of Biologically Active 2-Aminothiazol-4(5H)-one Derivatives
M Redka, S Baumgart, D Kupczyk, T Kosmalski… - International Journal of …, 2023 - mdpi.com
Pseudothiohydantoin derivatives have a wide range of biological activities and are widely
used in the development of new pharmaceuticals. Lipophilicity is a basic, but very important …
used in the development of new pharmaceuticals. Lipophilicity is a basic, but very important …
Novel 2-(Adamantan-1-ylamino)Thiazol-4(5H)-One Derivatives and Their Inhibitory Activity towards 11β-HSD1—Synthesis, Molecular Docking and In Vitro Studies
R Studzińska, D Kupczyk, W Płaziński… - International Journal of …, 2021 - mdpi.com
A common mechanism in which glucocorticoids participate is suggested in the pathogenesis
of such metabolic diseases as obesity, metabolic syndrome, or Cushing's syndrome. The …
of such metabolic diseases as obesity, metabolic syndrome, or Cushing's syndrome. The …
[PDF][PDF] Studzi nska
D Kupczyk - Clin. Med, 2022 - academia.edu
Glucocorticoids (GCs) belong to the group of steroid hormones. Their representative in
humans is cortisol. GCs are involved in most physiological processes of the body and play a …
humans is cortisol. GCs are involved in most physiological processes of the body and play a …
Facile one-pot, domino reaction to synthesize (Z)-2-imino-5-(1-alkyl-2-oxoindolin-3-ylidene)thiazolidin-4-one derivatives and its DFT study for the E/Z confirmation …
F Matloubi Moghaddam, L Kavoosi… - Synthetic …, 2023 - Taylor & Francis
In this publication, we reported an eco-friendly procedure for the efficient synthesis of 2-
imino-5-(1-alkyl-2-oxoindolin-3-ylidene) thiazolidin-4-one derivatives with a stereospecific …
imino-5-(1-alkyl-2-oxoindolin-3-ylidene) thiazolidin-4-one derivatives with a stereospecific …
Synthesis, characterization and biological activities of novel mononuclear nickel (II), copper (II) and chromium (III) complexes with N, N-dilaurylsubstituted thiazolidine …
MS Aksoy, A Yıldırım, AG Sarıkaya - 2024 - researchsquare.com
For the first time, a thiazolidine-4-one-5-acetic acid with two long hydrocarbon chains was
chosen as ligand and the corresponding metal complexes with Cr (III), Ni (II) and Cu (II) salts …
chosen as ligand and the corresponding metal complexes with Cr (III), Ni (II) and Cu (II) salts …
[PDF][PDF] Synthesis of Novel 2-(Cyclopentylamino) thiazol-4 (5H)-one Derivatives with Potential Anticancer, Antioxidant, and 11β-HSD Inhibitory Activities
S Baumgart, D Kupczyk, A Archała, O Koszła, P Sołek… - 2023 - ppm.umlub.pl
In this study, a series of nine new 2-(cyclopentylamino) thiazol-4 (5H)-one derivatives were
synthesized, and their anticancer, antioxidant, and 11β-hydroxysteroid dehydrogenase (11β …
synthesized, and their anticancer, antioxidant, and 11β-hydroxysteroid dehydrogenase (11β …
Evaluación bioinformática de metilfenilhidrazonas cristalinas y su potencial actividad farmacológica contra cáncer de tipo hormona-dependiente
M Hernández Aguilando - repositorioinstitucional.buap.mx
Abstract" En la presente investigación se utilizaron herramientas bioinformáticas para
analizar el potencial biológico de las moléculas derivadas de la metilfenilhidrazona frente a …
analizar el potencial biológico de las moléculas derivadas de la metilfenilhidrazona frente a …