Epigenetic alterations are associated with all aspects of cancer, from tumor initiation to
cancer progression and metastasis. It is now well understood that both losses and gains of …

Although the MYC oncogene has been implicated in cancer, a systematic assessment of
alterations of MYC, related transcription factors, and co-regulatory proteins, forming the …

Background Diffuse hemispheric gliomas, H3 G34-mutant (DHG H3G34-mutant) constitute a
distinct type of aggressive brain tumors. Although initially described in children, they can …

Neuroendocrine prostate cancer (NEPC) represents a highly aggressive form of prostate
tumors. NEPC results from trans-differentiated castration-resistant prostate cancer (CRPC) …

It has become increasingly evident that morphologically similar gliomas may have distinct
clinical phenotypes arising from diverse genetic signatures. To date, glial tumours from the …

H3G34 mutations occur in both pediatric non-brainstem high-grade gliomas (G34R/V) and
giant cell tumors of bone (G34W/L). Glioblastoma patients with G34R/V mutation have a …

Paediatric brain tumours (PBTs) are one of the most common cancers in children. Whilst
histone mutations, such as H3K27M and H3G34R/V, have been identified as major drivers …

Background. Diffuse hemispheric gliomas, H3 G34-mutant (DHG H3G34-mutant) constitute
a distinct type of aggressive brain tumors. Although initially described in children, they can …

Diffuse Gliome zeigen insgesamt eine eher schlechte Prognose, was unter anderem auf
intratumorale Heterogenität zurückzuführen ist. Molekulare Marker helfen dabei …