THE REQUIREMENT for making accurate and de-tailed assessments of organ function has
always depended on the scope and capabilities of available therapies. Over the past …

Interactions between the left ventricle (LV) and the arterial system,(ventricular–arterial
coupling) are key determinants of cardiovascular function. Ventricular–arterial coupling is …

Background The end-systolic pressure-volume relation (ESPVR) provides a useful measure
of contractile function. However, the need to acquire multiple cardiac cycles at varying loads …

Assessement of right ventricular (RV) contractility from end-systolic pressure-volume
relationships (ESPVR) is difficult due to problems in measuring RV instantaneous volume …

This study tests the hypothesis that arterial vascular stiffening adversely influences in situ left
ventricular contractile function and energetic efficiency. Ten reflex-blocked anesthetized …

This study assessed a new method of estimating the slope (Ees) of the end-systolic pressure-
volume relation (ESPVR) from a single beat of the human heart. Left ventricular pressure …

Aims In diabetes mellitus, heart failure with preserved ejection fraction (HFPEF) is a
significant comorbidity. No therapy is available that improves cardiovascular outcomes. The …

We developed a dynamic force-length (FL) control system for single intact cardiomyocytes
that uses a pair of compliant, computer-controlled, and piezo translator (PZT)-positioned …

Cardiothoracic open‐heart surgery has revolutionized the treatment of cardiovascular
disease, the leading cause of death worldwide. After the surgery, hemodynamic and volume …

Three measures of left ventricular (LV) performance derived from pressure (P)-volume (V)
loops have been proposed: the end-systolic PV (PES-VES) relation, the stroke work-end …