Over the past decade, melanoma has led the field in new cancer treatments, with impressive
gains in on-treatment survival but more modest improvements in overall survival. Melanoma …

Hair follicles are essential appendages of the mammalian skin, as hair performs vital
functions of protection, thermoregulation and sensation. Hair follicles harbour exceptional …

We present SCENIC, a computational method for simultaneous gene regulatory network
reconstruction and cell-state identification from single-cell RNA-seq data (http://scenic …

Tissues have a natural capacity to replace dying cells and to heal wounds. This ability
resides in resident stem cells, which self-renew, preserve, and repair their tissue during …

Empirical and anecdotal evidence has associated stress with accelerated hair greying
(formation of unpigmented hairs),, but so far there has been little scientific validation of this …

Background Extracellular matrix (ECM) is a dynamic and complex environment
characterized by biophysical, mechanical and biochemical properties specific for each …

The skin protects mammals from insults, infection and dehydration and enables
thermoregulation and sensory perception. Various skin-resident cells carry out these diverse …

Gene regulatory networks (GRNs) are key determinants of cell function and identity and are
dynamically rewired during development and disease. Despite decades of advancement …

Although CRISPR/Cas9 genome editing has provided numerous opportunities to interrogate
the functional significance of any given genomic site, there is a paucity of data on the extent …

The skin is the largest organ of the body and has an array of functions. Skin compartments,
epidermis, and hair follicles house stem cells that are indispensable for skin homeostasis …