Endogenous photosensitizers play a critical role in both beneficial and harmful light-induced
transformations in biological systems. Understanding their mode of action is essential for …

In recent years, accumulating evidence has elucidated the role of lysosomes in dynamically
regulating cellular and organismal homeostasis. Lysosomal changes and dysfunction have …

Pyroptosis is a gasdermin-mediated programmed necrosis that occurs via membrane
perforation and that can be exploited for biomedical applications in cancer therapy …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Photosensitization reactions have been demonstrated to be largely responsible for the
deleterious biological effects of UV and visible radiation, as well as for the curative actions of …

As an intracellular polyprotein complex, the NLRP3 inflammasome is activated by NLRP3
perceiving pathogen-related molecular patterns, damage-related molecular patterns …

Energy transfer to ground state triplet molecular oxygen results in the generation of singlet
molecular oxygen (1O2), which has potent oxidizing ability. Irradiation of light, notably …

Activatable prodrugs have drawn considerable attention for cancer cell ablation owing to
their high specificity in drug delivery systems. However, phototheranostic prodrugs with dual …

Cadmium (Cd), a predominant environmental pollutant, is a canonical toxicant that acts on
the kidneys. However, the nephrotoxic effect and underlying mechanism activated by …

Macroautophagy/autophagy can play a cytoprotective role after photodynamic damage to
malignant cells, depending on the site of subcellular damage initiated by reactive oxygen …