Protein cages: from fundamentals to advanced applications

TGW Edwardson, MD Levasseur, S Tetter… - Chemical …, 2022 - ACS Publications
Proteins that self-assemble into polyhedral shell-like structures are useful molecular
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …

Ferritin: a promising nanoreactor and nanocarrier for bionanotechnology

A Mohanty, A Parida, RK Raut… - ACS bio & med chem …, 2022 - ACS Publications
The essence of bionanotechnology lies in the application of nanotechnology/nanomaterials
to solve the biological problems. Quantum dots and nanoparticles hold potential biomedical …

Functional ferritin nanoparticles for biomedical applications

Z Wang, H Gao, Y Zhang, G Liu, G Niu… - Frontiers of chemical …, 2017 - Springer
Ferritin, a major iron storage protein with a hollow interior cavity, has been reported recently
to play many important roles in biomedical and bioengineering applications. Owing to the …

Iron, copper, and zinc homeostasis: Physiology, physiopathology, and nanomediated applications

R Szabo, C Bodolea, T Mocan - Nanomaterials, 2021 - mdpi.com
Understanding of how the human organism functions has preoccupied researchers in
medicine for a very long time. While most of the mechanisms are well understood and …

Vertasile ferritin nanocages: applications in detection and bioimaging

Y Chen, C Xu, M Sun, G Zhao, Z Wang, C Lv - Biosensors and …, 2024 - Elsevier
Food safety and human health remain significant concerns in the food industry. Detecting
food contaminants and diagnosing diseases are critical aspects. Ferritin, an iron storage …

Spatially controlled assembly of affinity ligand and enzyme cargo enables targeting ferritin nanocarriers to caveolae

VV Shuvaev, M Khoshnejad, KW Pulsipher… - Biomaterials, 2018 - Elsevier
One of the goals of nanomedicine is targeted delivery of therapeutic enzymes to the sub-
cellular compartments where their action is needed. Endothelial caveolae-derived …

Ferritin-based anticancer metallodrug delivery: Crystallographic, analytical and cytotoxicity studies

DM Monti, G Ferraro, A Merlino - Nanomedicine: Nanotechnology, Biology …, 2019 - Elsevier
The encapsulation of anticancer metal-based drugs within a protein nanocage represents a
valuable strategy to improve the efficacy and selectivity of these compounds towards cancer …

Nephron number and its determinants: a 2020 update

JR Charlton, EJ Baldelomar, DM Hyatt, KM Bennett - Pediatric Nephrology, 2021 - Springer
Studies of human nephron number have been conducted for well over a century and have
uncovered a large variability in nephron number. However, the mechanisms influencing …

Nanotechnology‐based strategies for early diagnosis of central nervous system disorders

S Hanif, P Muhammad, Z Niu, M Ismail… - Advanced …, 2021 - Wiley Online Library
Central nervous system (CNS) disorders feature the progressive and selective loss of
normal brain functions. CNS disorders often include an irreversible physiological and …

Nephron loss detected by MRI following neonatal acute kidney injury in rabbits

JR Charlton, EJ Baldelomar, KA deRonde… - Pediatric …, 2020 - nature.com
Background Acute kidney injury affects nearly 30% of preterm neonates in the intensive care
unit. We aimed to determine whether nephrotoxin-induced AKI disrupted renal development …