Chemistry for Positron Emission Tomography: Recent Advances in 11C‐, 18F‐, 13N‐, and 15O‐Labeling Reactions

X Deng, J Rong, L Wang, N Vasdev… - Angewandte Chemie …, 2019 - Wiley Online Library
Positron emission tomography (PET) is a molecular imaging technology that provides
quantitative information about function and metabolism in biological processes in vivo for …

Chemie der Positronenemissionstomographie: Aktuelle Fortschritte bei 11C‐, 18F‐, 13N‐und 15O‐Markierungsreaktionen

X Deng, J Rong, L Wang, N Vasdev… - Angewandte …, 2019 - Wiley Online Library
Die Positronenemissionstomographie (PET) ist ein molekulares bildgebendes Verfahren,
das in vivo quantitative Informationen über Funktion und Metabolismus bei biologischen …

[HTML][HTML] Efficient nitrogen-13 radiochemistry catalyzed by a highly stable immobilized biocatalyst

ES da Silva, V Gómez-Vallejo, J Llop… - Catalysis Science & …, 2015 - pubs.rsc.org
The continuous progress of nuclear imaging techniques demands the development and
implementation of efficient, clean and sustainable synthetic routes for the preparation of …

[HTML][HTML] Synthesis of radiolabelled aryl azides from diazonium salts: experimental and computational results permit the identification of the preferred mechanism

SM Joshi, A de Cózar, V Gómez-Vallejo… - Chemical …, 2015 - pubs.rsc.org
Experimental and computational studies on the formation of aryl azides from the
corresponding diazonium salts support a stepwise mechanism via acyclic zwitterionic …

Nitrogen‐13: historical review and future perspectives

V Gómez‐Vallejo, V Gaja, KB Gona… - Journal of Labelled …, 2014 - Wiley Online Library
Positron emission tomography is an ultra‐sensitive, in vivo molecular imaging technique that
allows the determination of the spatiotemporal distribution of a positron emitter labeled …

Current developments in the therapeutic potential of S-nitrosoglutathione, an endogenous NO-donor molecule

I Hornyák, E Pankotai, L Kiss… - Current Pharmaceutical …, 2011 - ingentaconnect.com
Nitric oxide (NO) has a role in many physiological processes and its decreased
concentration can lead to several pathophysiological events, therefore it is of considerable …

Synthesis of 13N‐labelled radiotracers by using microfluidic technology

V Gaja, V Gómez‐Vallejo… - Journal of Labelled …, 2012 - Wiley Online Library
Microfluidics has recently emerged as a useful alternative to traditional methods for the
preparation of radiotracers labelled with positron emitters. Up to date, microfluidics …

In Vitro Metabolic Stability and in Vivo Biodistribution of 3-Methyl-4-furoxancarbaldehyde Using PET Imaging in Rats

AB Pippin, ZH Mohd Arshad, RJ Voll… - ACS Medicinal …, 2016 - ACS Publications
Painful diabetic neuropathy (PDN) is a type of peripheral neuropathic pain that is currently
difficult to treat using clinically available analgesics. Recent work suggests a progressive …

A convenient synthesis of 13N-labelled azo compounds: a new route for the preparation of amyloid imaging PET probes

V Gómez-Vallejo, JI Borrell, J Llop - European journal of medicinal …, 2010 - Elsevier
In the present paper, a fast and automated method for the synthesis of 13N-labelled azo
compounds is reported for the first time. The labelling strategy is based on trapping [13N] …

[HTML][HTML] Synthesis of 13 N-labelled polysubstituted triazoles via Huisgen cycloaddition

SM Joshi, V Gómez-Vallejo, V Salinas, J Llop - RSC advances, 2016 - pubs.rsc.org
The use of the positron emitter nitrogen-13 (13N) has been historically restricted due to its
short half-life (T1/2= 9.97 min). However, its stable isotopes (nitrogen-14 and nitrogen-15) …