Ischemic cell death in brain neurons

P Lipton - Physiological reviews, 1999 - journals.physiology.org
This review is directed at understanding how neuronal death occurs in two distinct insults,
global ischemia and focal ischemia. These are the two principal rodent models for human …

Pathophysiology of perinatal brain damage

R Berger, Y Garnier - Brain Research Reviews, 1999 - Elsevier
Perinatal brain damage in the mature fetus is usually brought about by severe intrauterine
asphyxia following an acute reduction of the uterine or umbilical circulation. The areas most …

Amplitude-integrated EEG is useful in predicting neurodevelopmental outcome in full-term infants with hypoxic-ischemic encephalopathy: a meta-analysis

RE Spitzmiller, T Phillips… - Journal of child …, 2007 - journals.sagepub.com
Hypoxic ischemic encephalopathy is a common cause of neurological complications
resulting in chronic handicapping conditions, such as cerebral palsy. Amplitude-integrated …

Perinatal brain injury

R Berger, Y Garnier - 2000 - degruyter.com
Perinatal brain damage in the mature fetus is usually brought about by severe intrauterine
asphyxia following an acute reduction of the uterine or umbilical circulation. The areas most …

The effect of prenatal hypoxia on brain development: short‐and long‐term consequences demonstrated in rodent models

H Golan, M Huleihel - Developmental Science, 2006 - Wiley Online Library
Hypoxia (H) and hypoxia‐ischemia (HI) are major causes of foetal brain damage with long‐
lasting behavioral implications. The effect of hypoxia has been widely studied in human and …

Impairment of mitochondrial respiration after cerebral hypoxia–ischemia in immature rats: relationship to activation of caspase-3 and neuronal injury

M Puka-Sundvall, C Wallin, E Gilland, U Hallin… - Developmental Brain …, 2000 - Elsevier
Mitochondrial damage may play a key role in the development of necrotic and apoptotic
hypoxic–ischemic (HI) brain damage. It has previously been shown that mitochondrial …

Apoptosis in perinatal hypoxic–ischemic brain injury: how important is it and should it be inhibited?

FJ Northington, EM Graham, LJ Martin - Brain research reviews, 2005 - Elsevier
The discovery of safe and effective therapies for perinatal hypoxia–ischemia (HI) and stroke
remains an unmet goal of perinatal medicine. Hypothermia and antioxidants such as …

Cell death, axonal damage, and cell birth in the immature rat brain following induction of hydrocephalus

MR Del Bigio, YW Zhang - Experimental neurology, 1998 - Elsevier
We hypothesized that hydrocephalus can cause death of brain cells and that generation of
new brain cells might compensate for the cell loss. Hydrocephalus was induced in 3-week …

Episodic neonatal hypoxia evokes executive dysfunction and regionally specific alterations in markers of dopamine signaling

MJ Decker, GE Hue, WM Caudle, GW Miller… - Neuroscience, 2003 - Elsevier
Perinatal ischemic–anoxic and prolonged anoxic insults lead to impaired dopaminergic
signaling and are hypothesized to contribute, at least in part, to the pathogenesis of …

Brief update on animal models of hypoxic-ischemic encephalopathy and neonatal stroke

FJ Northington - ILAR journal, 2006 - academic.oup.com
The discovery of safe and effective therapies for perinatal hypoxia ischemia (HI) and stroke
remains an unmet goal of neonatal-perinatal medicine. Because of the many developmental …