Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt pathway plays a crucial role in various
cellular processes and is aberrantly activated in cancers, contributing to the occurrence and …

Two related developments are currently changing traditional approaches to computational
systems biology modelling. First, stochastic models are being used increasingly in …

Cellular senescence—the permanent arrest of cycling in normally proliferating cells such as
fibroblasts—contributes both to age‐related loss of mammalian tissue homeostasis and acts …

Cancer is now appreciated as not only a highly heterogenous pathology with respect to cell
type and tissue origin but also as a disease involving dysregulation of multiple pathways …

Cells living in a complex environment must constantly detect, process and appropriately
respond to changing signals. Therefore, all cellular information processing is dynamic in …

The protein p53 functions as a tumor suppressor and can trigger either cell cycle arrest or
apoptosis in response to DNA damage. We used Boolean network modeling and attractor …

The aging process is driven at the cellular level by random molecular damage that slowly
accumulates with age. Although cells possess mechanisms to repair or remove damage …

Ageing is intrinsically complex, being driven by multiple causal mechanisms. Each
mechanism tends to be partially supported by data indicating that it has a role in the overall …

Mesenchymal stromal/stem cells (MSCs) are multipotent cells that can differentiate to
various specialized cells, which have the potential capacity to differentiate properly and …

BioModels is a reference repository hosting mathematical models that describe the dynamic
interactions of biological components at various scales. The resource provides access to …