Anticoagulant therapy is the cornerstone of treatment and prevention of arterial and venous
thromboembolism. Taking a historical perspective, starting in the 1960s, and progressing …

Introduction: Dabigatran, a direct thrombin inhibitor, is 80% renally eliminated and
demonstrates multi-compartmental pharmacokinetics. Idarucizumab is a monoclonal …

Objectives The thrombin inhibitor dabigatran is mainly excreted by the kidneys. We
investigated whether the recommended method for estimation of renal function used in the …

Aims Dabigatran is largely cleared by renal excretion. Renal function is thus a major
determinant of trough dabigatran concentrations, which correlate with the risk of …

Background Anticoagulants such as warfarin and dabigatran can significantly reduce the
risk of stroke in individuals with atrial fibrillation that may lead to increased risk of bleeding …

Dabigatran is an oral anticoagulant that is increasingly used for atrial fibrillation (AF).
Presently, many authorities state that routine laboratory coagulation monitoring is not …

Background It is unclear which renal function equation, employing an isotope dilution mass
spectrometry (IDMS)-aligned creatinine assay, best predicts gentamicin clearance. Methods …

Aims In patients with atrial fibrillation prescribed dabigatran, the aim was to examine the
correlation between plasma dabigatran concentrations and the three screening coagulation …

Dabigatran etexilate is an oral direct thrombin inhibitor used in preventing thromboembolism
in patients with atrial fibrillation and several other conditions. Routine dabigatran …

Background Dabigatran etexilate may be underutilized in geriatric patients because of
inadequate clinical experience in individuals with severe renal impairment and post …