Multi-omics integration in biomedical research–A metabolomics-centric review
Recent advances in high-throughput technologies have enabled the profiling of multiple
layers of a biological system, including DNA sequence data (genomics), RNA expression …
layers of a biological system, including DNA sequence data (genomics), RNA expression …
Alzheimer's pathogenic mechanisms and underlying sex difference
AD is a neurodegenerative disease, and its frequency is often reported to be higher for
women than men: almost two-thirds of patients with AD are women. One prevailing view is …
women than men: almost two-thirds of patients with AD are women. One prevailing view is …
Mapping the proteo-genomic convergence of human diseases
INTRODUCTION Proteins are essential functional units of the human body and represent
the largest class of drug targets. RATIONALE Broad-capture proteomics has the potential to …
the largest class of drug targets. RATIONALE Broad-capture proteomics has the potential to …
Sex differences in cancer mechanisms
JB Rubin, JS Lagas, L Broestl, J Sponagel… - Biology of sex …, 2020 - Springer
We now know that cancer is many different diseases, with great variation even within a
single histological subtype. With the current emphasis on developing personalized …
single histological subtype. With the current emphasis on developing personalized …
Analysis of the human adult urinary metabolome variations with age, body mass index, and gender by implementing a comprehensive workflow for univariate and …
EA Thévenot, A Roux, Y Xu, E Ezan… - Journal of proteome …, 2015 - ACS Publications
Urine metabolomics is widely used for biomarker research in the fields of medicine and
toxicology. As a consequence, characterization of the variations of the urine metabolome …
toxicology. As a consequence, characterization of the variations of the urine metabolome …
The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease
A multitude of factors contribute to complex diseases and can be measured with 'omics'
methods. Databases facilitate data interpretation for underlying mechanisms. Here, we …
methods. Databases facilitate data interpretation for underlying mechanisms. Here, we …
A global view of the genetic basis of Alzheimer disease
C Reitz, MA Pericak-Vance, T Foroud… - Nature Reviews …, 2023 - nature.com
The risk of Alzheimer disease (AD) increases with age, family history and informative genetic
variants. Sadly, there is still no cure or means of prevention. As in other complex diseases …
variants. Sadly, there is still no cure or means of prevention. As in other complex diseases …
Sex differences in metabolic homeostasis, diabetes, and obesity
F Mauvais-Jarvis - Biology of sex differences, 2015 - Springer
There are fundamental aspects of the control of metabolic homeostasis that are regulated
differently in males and females. This sex asymmetry represents an evolutionary paradigm …
differently in males and females. This sex asymmetry represents an evolutionary paradigm …
Microbial endocrinology: the interplay between the microbiota and the endocrine system
The new field of microbiome research studies the microbes within multicellular hosts and the
many effects of these microbes on the host's health and well-being. We now know that …
many effects of these microbes on the host's health and well-being. We now know that …
Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity
JGM Markle, DN Frank, S Mortin-Toth, CE Robertson… - Science, 2013 - science.org
Microbial exposures and sex hormones exert potent effects on autoimmune diseases, many
of which are more prevalent in women. We demonstrate that early-life microbial exposures …
of which are more prevalent in women. We demonstrate that early-life microbial exposures …