Human factor VIII—von Willebrand factor (vWF) is a large, multimeric glycoprotein that plays
a central role in the blood coagulation system, serving both as a carrier for factor VIIIC …

The binding of plasma von Willebrand factor (VWF) to platelet receptor GpIb under high
hydrodynamic shear leads to platelet activation and subsequent shear-induced platelet …

We have used recombinant wild-type human von Willebrand factor (VWF) and deletion
mutants lacking the A1 and A3 domains, as well as specific function-blocking monoclonal …

The biosynthesis of von Willebrand Factor (vWF) by vascular endothelial cells involves a
complex series of processing steps that includes pyteolytic cleavage of a 74% residue …

Large von Willebrand factor (vWf) multimers are assembled by the formation of disulfide
bonds between dimers in trans Golgi and post-Golgi compartments. We were able to …

von Willebrand factor (VWF) is a large, adhesive glycoprotein that is biosynthesized and
secreted by cultured endothelial cells (EC). Although these cells constitutively release VWF …

Recently, substantial progress has been made in our knowledge of the domains involved in
correlating structure and function of vWF, as well as in the biosynthesis and assembly of …

von Willebrand factor (VWF) is the largest multimeric adhesion ligand circulating in blood. Its
adhesion activity is related to multimer size, with the ultra-large forms freshly released from …

Interchain disulfide bonds between the subunits in von Willebrand factor (vWf) dimers and in
vWf multimers have been studied using some unique features of the cultured human …

Von Willebrand factor (VWF) is a plasma glycoprotein that circulates noncovalently bound to
blood coagulation factor VIII (fVIII). VWF is a population of multimers composed of a variable …