The clinical diagnosis of Parkinson's disease rests on the identification of the characteristics
related to dopamine deficiency that are a consequence of degeneration of the substantia …

Parkinson disease (PD) is an age-related neurodegenerative disorder that affects as many
as 1–2% of persons aged 60 years and older. With the aging of the population, the …

Idiopathic REM sleep behaviour disorder (iRBD) is a powerful early sign of Parkinson's
disease, dementia with Lewy bodies, and multiple system atrophy. This provides an …

The microbiota-gut-brain axis has been suggested to play an important role in Parkinson's
disease (PD). Here we performed a cross-sectional study to profile gut microbiota across …

Abstract Objective The Parkinson's Progression Markers Initiative (PPMI) is an
observational, international study designed to establish biomarker‐defined cohorts and …

Background Increasing evidence connects the gut microbiota and the onset and/or
phenotype of Parkinson's disease (PD). Differences in the abundances of specific bacterial …

Parkinson's disease varies widely in clinical manifestations, course of progression and
biomarker profiles from person to person. Identification of distinct Parkinson's disease …

Background and Objectives Owing to the lack of long-term observations or comprehensive
adjustment for confounding factors, reliable conclusions regarding long-term effects of …

Isolated REM sleep behaviour disorder (RBD) is an early-stage α-synucleinopathy in most, if
not all, affected subjects. Detection of pathological α-synuclein in peripheral tissues of …

Nonmotor symptoms (NMS) in Parkinson's disease (PD) can precede onset of motor
symptoms. Relationship between premotor symptoms onset and motor features is limited …