Cartilage injury remains a major challenge in orthopedic surgery due to the fact that articular
cartilage has only a limited capacity for intrinsic healing. Cartilage impaction is followed by a …

Numerous studies have assembled a complex picture, in which extracellular stimuli and
intracellular signaling pathways modulate the chondrocyte phenotype. Because many …

The differentiated phenotype of chondrocytes from hyaline cartilage is gradually lost during
expansion in monolayers. Chondrocytes can reexpress their differentiated phenotype by …

Cell number is often a limiting factor in studies of chondrocyte physiology, particularly for
human investigations. Chondrocytes can be readily proliferated in monolayer culture …

Chondrocytes cultivated in monolayer rapidly divide and lose their morphological and
biochemical characteristics, whereas they maintain their phenotype for long periods of time …

The application of tissue engineering to generate cartilage is limited because of low
proliferative ability and unstable phenotype of chondrocytes. The sources of cartilage seed …

During chondrogenesis, complex intracellular signalling pathways regulate an intricate
series of events including condensation of chondroprogenitor cells and nodule formation …

Chondrocytes rapidly lose their phenotypic expression of collagen II and aggrecan when
grown on 2D substrates. It has generally been observed that a fibroblastic morphology with …

Articular cartilage displays a limited capacity of self-regeneration after injury. Thus, the
biology of this tissue and its cellular components–the chondrocytes–has become the focus …

The objective of the study was to directly measure the force of contraction of adult articular
chondrocytes and to examine their contractile behavior in collagen-glycosaminoglycan …