Ion channels play important roles in fundamental biological processes, such as electric
signaling in cells, muscle contraction, hormone secretion, and regulation of the immune …

Psychostimulant drugs, such as cocaine, inhibit dopamine reuptake via blockading the
dopamine transporter (DAT), which is the primary mechanism underpinning their abuse …

The Colombian scorpion Centruroides margaritatus produces a venom considered of low
toxicity. Nevertheless, there are known cases of envenomation resulting in cardiovascular …

A cationic leak current known as an" omega current" may arise from mutations of the first
charged residue in the S4 of the voltage sensor domains of sodium and potassium voltage …

By assuming that a stepwise outward movement of the four S4 segments of the hERG
potassium channel determines a concomitant progressive increase in the flow of the …

Membranes are complex cellular structures consisting of many different lipid types, a variety
of bound proteins, and other molecules. Growing evidence suggests that membranes and …

A myriad of cellular responses is dependent on selective membrane-permeation of charged
species through membrane proteins known as ion channels. Among them, the ryanodine …