In this review, we summarize the multiple functions of NQO1, its established roles in redox
processes and potential roles in redox control that are currently emerging. NQO1 has …

Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents
to treat solid tumors including ovarian, head and neck, and testicular germ cell tumors. A …

NQO1 is one of the two major quinone reductases in mammalian systems. It is highly
inducible and plays multiple roles in cellular adaptation to stress. A prevalent polymorphic …

For many years, the ubiquitin-26S proteasome degradation pathway was considered the
primary route for proteasomal degradation. However, it is now becoming clear that proteins …

Cisplatin is one of the most widely used and highly effective drug for the treatment of various
solid tumors; however, it has dose-dependent side effects on the kidney, cochlear, and …

The last decade has seen accumulating evidence of various proteins being degraded by the
core 20S proteasome, without its regulatory particle (s). Here, we will describe recent …

To investigate the influence of Moringa seed extract (MSE) on the cerebral Nrf2/NQO1
signaling in TiO 2-NPs–induced brain damage, 80 male albino rats were divided into four …

Controlled degradation of proteins is necessary for ensuring their abundance and sustaining
a healthy and accurately functioning proteome. One of the degradation routes involves the …

The ubiquitin–proteasome system fulfills an essential role in regulating protein homeostasis
by spatially and temporally controlling proteolysis in an ATP-and ubiquitin-dependent …

Abstract The Ubiquitin Proteasome System (UPS) was discovered in two steps. Initially, APF-
1 (ATP-dependent proteolytic Factor 1) later identified as ubiquitin (Ub), a hitherto known …