The aggregation of a polypeptide chain into amyloid fibrils and their accumulation and
deposition into insoluble plaques and intracellular inclusions is the hallmark of several …

The formation of insulin amyloid can dramatically impact glycemic control in patients with
diabetes, making it an important therapeutic consideration. In addition, the cost associated …

One prevention and therapeutic strategy for diseases associated with peptide or protein
fibrillation is to inhibit or delay the fibrillation process. Carbon dots (C–Dots) have recently …

Drug delivery to the central nervous system (CNS) in biological systems remains a major
medical challenge due to the tight junctions between endothelial cells known as the blood …

Nitrogen-doped carbon dots (N-CDs) were synthesized using a one-pot hydrothermal
treatment with citric acid in the presence of polyethylenimine. Transmission electron …

Primary nucleation is the fundamental event that initiates the conversion of proteins from
their normal physiological forms into pathological amyloid aggregates associated with the …

This review article summarises the possible mechanisms of the protein-ligand interaction,
folding, misfolding, aggregation and inhibition of protein aggregates. Under certain stressed …

Association and dissociation of proteins are important biochemical events. In this Feature
Article, we analyze the available studies of these processes for insulin oligomers in aqueous …

We use vibrational sum-frequency generation (VSFG) spectroscopy to study the structure of
hen egg-white lysozyme (HEWL) aggregates adsorbed to DOPG/D2O and air/D2O …

Human diseases characterized by the uncontrolled deposition of insoluble extracellular
protein aggregates are collectively referred to as amyloidoses. Such diseases include …