Embracing the era of antimicrobial peptides with marine organisms

P Chen, T Ye, C Li, P Praveen, Z Hu, W Li… - Natural Product …, 2024 - pubs.rsc.org
Covering: 2018 to Jun of 2023 The efficiency of traditional antibiotics has been undermined
by the proliferation of antibiotic-resistant pathogenic microorganisms, necessitating the …

Marine resources offer new compounds and strategies for the treatment of skin and soft tissue infections

A Labes - Marine Drugs, 2023 - mdpi.com
Bioprospecting of the marine environment for drug development has gained much attention
in recent years owing to its massive chemical and biological diversity. Drugs for the …

A review of current antibiotic resistance and promising antibiotics with novel modes of action to combat antibiotic resistance

L Chen, S Kumar, H Wu - Archives of Microbiology, 2023 - Springer
The emergence and transmission of antibiotic resistance is a global public health crisis with
significant burden on healthcare systems, resulting in high mortality and economic costs. In …

“AMP plus”: Immunostimulant-Inspired Design Based on Chemotactic Motif-(PhHAhPH)n

Y Zhu, Y Xu, J Yan, Y Fang, N Dong… - ACS Applied Materials & …, 2023 - ACS Publications
Ability to stimulate antimicrobial immunity has proven to be a useful therapeutic strategy in
treating infections, especially in the face of increasing antibiotic resistance. Natural …

Novel antimicrobial peptide DvAMP serves as a promising antifungal agent against Cryptococcus neoformans

L Yang, Z Tian, W Zhao, J Zhang, C Tian, L Zhou… - Bioorganic …, 2023 - Elsevier
Cryptococcus neoformans is an important opportunistic human fungal pathogen that causes
cryptococcosis in immunocompromised patients. However, the number of drugs for the …

Thinking on the construction of antimicrobial peptide databases: Powerful tools for the molecular design and screening

K Zhang, D Teng, R Mao, N Yang, Y Hao… - International Journal of …, 2023 - mdpi.com
With the accelerating growth of antimicrobial resistance (AMR), there is an urgent need for
new antimicrobial agents with low or no AMR. Antimicrobial peptides (AMPs) have been …

Helminthic host defense peptides: using the parasite to defend the host

I Mladineo, T Rončević, M Gerdol, A Tossi - Trends in parasitology, 2023 - cell.com
Parasitic helminths are destined to share niches with a variety of microbiota that inevitably
influence their interaction with the host. To modulate the microbiome for their benefit and …

Simulation study of the effect of antimicrobial peptide associations on the mechanism of action with bacterial and eukaryotic membranes

M Maleš, L Zoranić - Membranes, 2022 - mdpi.com
Antimicrobial peptides (AMPs) can be directed to specific membranes based on differences
in lipid composition. In this study, we performed atomistic and coarse-grained simulations of …

Relating molecular dynamics simulations to functional activity for gly-rich membranolytic helical kiadin peptides

T Rončević, M Maleš, Y Sonavane, F Guida, S Pacor… - Pharmaceutics, 2023 - mdpi.com
Kiadins are in silico designed peptides with a strong similarity to di PGLa-H, a tandem
sequence of PGLa-H (KIAKVALKAL) and with single, double or quadruple glycine …

Dual‐Mechanism Peptide SR25 has Broad Antimicrobial Activity and Potential Application for Healing Bacteria‐infected Diabetic Wounds

XY Luo, CM Hu, Q Yin, XM Zhang, ZZ Liu… - Advanced …, 2024 - Wiley Online Library
The rise of antibiotic resistance poses a significant public health crisis, particularly due to
limited antimicrobial options for the treatment of infections with Gram‐negative pathogens …