Multiple myeloma (MM) is the second most common blood cancer. Treatments for MM
include corticosteroids, alkylating agents, anthracyclines, proteasome inhibitors …

Over the past 4 decades, basic research has provided crucial information regarding the
cellular and molecular biology of cancer. In particular, the relevance of cancer …

Objective Current treatments for systemic lupus erythematosus (SLE) and vasculitis
contribute to mortality and incapacity and are only partially effective; thus, newer therapies …

CXC motif chemokine receptor 3 (CXCR3) and CXCR4 expressed on immunoglobulin G
(IgG)–plasma-cell precursors formed in memory immune responses are crucial modulators …

The pathogenic roles of B cells in human autoimmune diseases involve a multitude of
mechanistic pathways and include the well-established contributions of autoantibodies and …

Idiopathic membranous nephropathy is still the most common glomerular disease
associated with nephrotic syndrome. The greater the proteinuria, the greater the long-term …

Answer questions and earn CME/CNE Multiple myeloma (MM) is a cancer of antibody‐
producing plasma cells. The pathognomonic laboratory finding is a monoclonal …

Krüppel-like factor 2 (KLF2) controls T lymphocyte egress from lymphoid organs by
regulating sphingosin-1 phosphate receptor 1 (S1Pr1). Here we show that this is not the …

To understand the modulation of dendritic cell (DC) function by IL-10, gene expression
profiling was performed by using Affymetrix technology (Santa Clara, CA) in human …

Human Toll-like receptor 8 (hTLR8) is expressed in myeloid dendritic cells, monocytes, and
monocyte-derived dendritic cells. Engagement by TLR8 agonists evokes a distinct cytokine …