Microfluidic-based technologies for CTC isolation: a review of 10 years of intense efforts towards liquid biopsy

L Descamps, D Le Roy, AL Deman - International Journal of Molecular …, 2022 - mdpi.com
The selection of circulating tumor cells (CTCs) directly from blood as a real-time liquid
biopsy has received increasing attention over the past ten years, and further analysis of …

Advances in microfluidics: technical innovations and applications in diagnostics and therapeutics

G Aubry, HJ Lee, H Lu - Analytical Chemistry, 2023 - ACS Publications
Microfluidics describes the study of systems that operate fluids at miniature scales, often in
microchannels. It is powerful in scaling down biological experiments by many orders of …

Geometric structure design of passive label-free microfluidic systems for biological micro-object separation

H Tang, J Niu, H Jin, S Lin, D Cui - Microsystems & Nanoengineering, 2022 - nature.com
Passive and label-free microfluidic devices have no complex external accessories or
detection-interfering label particles. These devices are now widely used in medical and …

[HTML][HTML] Microfluidic technology and its application in the point-of-care testing field

Y Xie, L Dai, Y Yang - Biosensors and Bioelectronics: X, 2022 - Elsevier
Since the outbreak of the coronavirus disease 2019 (COVID-19), countries around the world
have suffered heavy losses of life and property. The global pandemic poses a challenge to …

Recent progress of inertial microfluidic-based cell separation

X Xu, X Huang, J Sun, R Wang, J Yao, W Han, M Wei… - Analyst, 2021 - pubs.rsc.org
Cell separation has consistently been a pivotal technology of sample preparation in
biomedical research. Compared with conventional bulky cell separation technologies …

Tunable velocity-based deterministic lateral displacement for efficient separation of particles in various size ranges

A Kheirkhah Barzoki, R Dezhkam, A Shamloo - Physics of Fluids, 2023 - pubs.aip.org
Deterministic lateral displacement (DLD) is a promising method showing great potential in
achieving high-resolution separation of suspended particles based on their size, through the …

MagPure chip: an immunomagnetic-based microfluidic device for high purification of circulating tumor cells from liquid biopsies

L Descamps, J Garcia, D Barthelemy, E Laurenceau… - Lab on a Chip, 2022 - pubs.rsc.org
The isolation of circulating tumor cells (CTCs) directly from blood, as a liquid biopsy, could
lead to a paradigm shift in cancer clinical care by providing an earlier diagnosis, a more …

Advances in novel strategies for isolation, characterization, and analysis of CTCs and ctDNA

V Yaghoubi Naei, P Bordhan… - Therapeutic …, 2023 - journals.sagepub.com
Over the past decade, the detection and analysis of liquid biopsy biomarkers such as
circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) have advanced …

Application of microfluidics in detection of circulating tumor cells

C Li, W He, N Wang, Z Xi, R Deng, X Liu… - … in Bioengineering and …, 2022 - frontiersin.org
Tumor metastasis is one of the main causes of cancer incidence and death worldwide. In the
process of tumor metastasis, the isolation and analysis of circulating tumor cells (CTCs) …

[HTML][HTML] Continuous centrifugal microfluidics (CCM) isolates heterogeneous circulating tumor cells via full automation

HJ Woo, SH Kim, HJ Kang, SH Lee, SJ Lee, JM Kim… - Theranostics, 2022 - ncbi.nlm.nih.gov
Understanding cancer heterogeneity is essential to finding diverse genetic mutations in
metastatic cancers. Thus, it is critical to isolate all types of CTCs to identify accurate cancer …