Each cell is equipped with a conserved housekeeping mechanism, known as autophagy, to
recycle exhausted materials and dispose of injured organelles via lysosomal degradation …

Age-related macular degeneration (AMD) is a complex, multifactorial, progressive retinal
disease that affects millions of people worldwide and has become the leading cause of …

The liver is in charge of a wide range of critical physiological processes and it plays an
important role in activating the innate immune system which elicits the inflammatory events …

Ciliopathies manifest from sensory abnormalities to syndromic disorders with multi-organ
pathologies, with retinal degeneration a highly penetrant phenotype. Photoreceptor cell …

Oxygen reactive species (ROS) are a group of molecules generated from the incomplete
reduction of oxygen. Due to their high reactivity, ROS can interact with and influence the …

One in three cancer deaths worldwide are caused by gastric and colorectal cancer
malignancies. Although the incidence and fatality rates differ significantly from country to …

Age-related macular degeneration is a common cause of blindless among the aged, which
can mainly be attributed to oxidative stress and dysregulated autophagy in retinal pigment …

The retinal pigment epithelium (RPE) performs a range of necessary functions within the
neural layers of the retina and helps ensure vision. The regulation of pro-oxidative and …

Retinal neurodegeneration plays a significant role in the pathogenesis of diabetic
retinopathy, the leading cause of preventable blindness. The hallmarks of diabetes-induced …

Ferroptosis is a new form of programmed cell death (PCD) characterized by an excess iron
accumulation and subsequent unbalanced redox states. Ferroptosis is different from the …