Since the first place cell was recorded and the cognitive-map theory was subsequently
formulated, investigation of spatial representation in the hippocampal formation has evolved …

Theories on the functions of the hippocampal system are based largely on two fundamental
discoveries: the amnestic consequences of removing the hippocampus and associated …

Neural circuits construct distributed representations of key variables—external stimuli or
internal constructs of quantities relevant for survival, such as an estimate of one's location in …

A longstanding goal in neuroscience has been to image membrane voltage across a
population of individual neurons in an awake, behaving mammal. Here we describe a …

The hippocampus and its associated cortical regions in the medial temporal lobe play
essential roles when animals form a cognitive map and use it to achieve their goals. As the …

Classic computational theories of the mnemonic functions of the hippocampus ascribe the
processes of pattern separation to the dentate gyrus (DG) and pattern completion to the CA3 …

Many animals rely on an internal heading representation when navigating in varied
environments,,,,,,,,–. How this representation is linked to the sensory cues that define …

As animals explore an environment, the hippocampus is thought to automatically form and
maintain a place code by combining sensory and self-motion signals. Instead, we observed …

Identifying the scope and nature of memory processing by the hippocampus has proved a
formidable challenge. The major initial insights came from studies of amnesia in human …

We used fluorescent in-situ hybridization and confocal microscopy to monitor the subcellular
distribution of the immediate-early gene Arc. Arc RNA appeared in discrete intranuclear foci …