Nucleic acids, including deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are
natural biopolymers composed of nucleotides that store, transmit, and express genetic …

The discovery of glucagon-like peptide-1 (GLP-1), an incretin hormone with important effects
on glycemic control and body weight regulation, led to efforts to extend its half-life and make …

Early-life determinants are thought to be a major factor in the rapid increase of obesity.
However, while maternal nutrition has been extensively studied, the effects of breastfeeding …

Abstract The purinoceptor P2X 7 R is a promising therapeutic target for tauopathies,
including Alzheimer's disease (AD). Pharmacological inhibition or genetic knockdown of …

Abstract N, N-dimethyltryptamine (DMT), a psychedelic compound identified endogenously
in mammals, is biosynthesized by aromatic-L-amino acid decarboxylase (AADC) and …

Nucleic acid sequence variations have been implicated in many diseases, and reliable
detection and quantitation of DNA/RNA biomarkers can inform effective therapeutic action …

Engineered variants of recombinant adeno-associated viruses (rAAVs) are being developed
rapidly to meet the need for gene-therapy delivery vehicles with particular cell-type and …

The RNA modification N6-methyladenosine (m6A) regulates the interaction between RNA
and various RNA binding proteins within the nucleus and other subcellular compartments …

Neuropeptides are auxiliary messenger molecules that always co-exist in nerve cells with
one or more small molecule (classic) neurotransmitters. Neuropeptides act both as …

Spatiotemporal control of Wnt signaling is essential for the development and homeostasis of
many tissues. The transmembrane E3 ubiquitin ligases ZNRF3 (zinc and ring finger 3) and …