Health implications of high dietary omega‐6 polyunsaturated fatty acids

E Patterson, R Wall, GF Fitzgerald… - Journal of nutrition …, 2012 - Wiley Online Library
Omega‐6 (n‐6) polyunsaturated fatty acids (PUFA)(eg, arachidonic acid (AA)) and omega‐3
(n‐3) PUFA (eg, eicosapentaenoic acid (EPA)) are precursors to potent lipid mediator …

Long-chain polyunsaturated fatty acids (LCPUFA) from genesis to senescence: the influence of LCPUFA on neural development, aging, and neurodegeneration

CIF Janssen, AJ Kiliaan - Progress in lipid research, 2014 - Elsevier
Many clinical and animal studies demonstrate the importance of long-chain polyunsaturated
fatty acids (LCPUFA) in neural development and neurodegeneration. This review will focus …

Brain fuel metabolism, aging, and Alzheimer's disease

S Cunnane, S Nugent, M Roy, A Courchesne-Loyer… - Nutrition, 2011 - Elsevier
Lower brain glucose metabolism is present before the onset of clinically measurable
cognitive decline in two groups of people at risk of Alzheimer's disease---carriers of …

Microalgae as sources of omega-3 polyunsaturated fatty acids: Biotechnological aspects

DG Barta, V Coman, DC Vodnar - Algal Research, 2021 - Elsevier
Recent advances in functional foods and nutraceuticals have emphasized the beneficial
impact of bioactive molecules on human health and longevity. The omega-3 (ω-3) long …

Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression

ME Sublette, SP Ellis, AL Geant… - The Journal of clinical …, 2011 - psychiatrist.com
Objective: Randomized trials of omega-3 polyunsaturated fatty acid (PUFA) treatment for
depression have differed in outcome. Recent meta-analyses ascribe discrepancies to …

Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements

M Plourde, SC Cunnane - Applied physiology, nutrition, and …, 2007 - cdnsciencepub.com
There is considerable interest in the potential impact of several polyunsaturated fatty acids
(PUFAs) in mitigating the significant morbidity and mortality caused by degenerative …

Fish, docosahexaenoic acid and Alzheimer's disease

SC Cunnane, M Plourde, F Pifferi, M Bégin… - Progress in lipid …, 2009 - Elsevier
Cognitive decline in the elderly, particularly Alzheimer's disease (AD), is a major socio-
economic and healthcare concern. We review here the literature on one specific aspect of …

Dietary DHA and health: cognitive function ageing

C Cardoso, C Afonso, NM Bandarra - Nutrition Research Reviews, 2016 - cambridge.org
DHA is a key nutritional n-3 PUFA and needs to be supplied by the human diet. DHA is
found in significant amounts in the retinal and neuronal cell membranes due to its high …

Neuroketotherapeutics: a modern review of a century-old therapy

SJ Koppel, RH Swerdlow - Neurochemistry international, 2018 - Elsevier
Neuroketotherapeutics represent a class of bioenergetic medicine therapies that feature the
induction of ketosis. These therapies include medium-chain triglyceride supplements …

[HTML][HTML] Lipids: An insight into the neurodegenerative disorders

A Shamim, T Mahmood, F Ahsan, A Kumar… - Clinical Nutrition …, 2018 - Elsevier
Brain development is a sequential anatomical process characterised by specific well-
defined stages of growth and maturation. One of the fundamental and necessary events in …