[HTML][HTML] Human CtIP: A 'double agent'in DNA repair and tumorigenesis
NL Mozaffari, F Pagliarulo, AA Sartori - Seminars in cell & developmental …, 2021 - Elsevier
Human CtIP was originally identified as an interactor of the retinoblastoma protein and
BRCA1, two bona fide tumour suppressors frequently mutated in cancer. CtIP is renowned …
BRCA1, two bona fide tumour suppressors frequently mutated in cancer. CtIP is renowned …
Molecular insights into the activation of Mre11-Rad50 endonuclease activity by Sae2/CtIP
In Saccharomyces cerevisiae (S. cerevisiae), Mre11-Rad50-Xrs2 (MRX)-Sae2 nuclease
activity is required for the resection of DNA breaks with secondary structures or protein …
activity is required for the resection of DNA breaks with secondary structures or protein …
DNA binding and bridging by human CtIP in the healthy and diseased states
S Lokanathan Balaji, S De Bragança… - Nucleic acids …, 2024 - academic.oup.com
The human DNA repair factor CtIP helps to initiate the resection of double-stranded DNA
breaks for repair by homologous recombination, in part through its ability to bind and bridge …
breaks for repair by homologous recombination, in part through its ability to bind and bridge …
Inter-generational nuclear crosstalk links the control of gene expression to programmed genome rearrangement during the Paramecium sexual cycle
M Bazin-Gélis, E Eleftheriou, C Zangarelli… - Nucleic Acids …, 2023 - academic.oup.com
Multinucleate cells are found in many eukaryotes, but how multiple nuclei coordinate their
functions is still poorly understood. In the cytoplasm of the ciliate Paramecium tetraurelia …
functions is still poorly understood. In the cytoplasm of the ciliate Paramecium tetraurelia …
A stapled peptide mimetic of the CtIP tetramerization motif interferes with double-strand break repair and replication fork protection
A Kuster, NL Mozaffari, OJ Wilkinson, JL Wojtaszek… - Science …, 2021 - science.org
Cancer cells display high levels of DNA damage and replication stress, vulnerabilities that
could be exploited by drugs targeting DNA repair proteins. Human CtIP promotes homology …
could be exploited by drugs targeting DNA repair proteins. Human CtIP promotes homology …
RNAi screening uncovers a synthetic sick interaction between CtIP and the BARD1 tumor suppressor
HA Bolck, S Przetocka, R Meier, C Von Aesch… - Cells, 2022 - mdpi.com
Human CtIP is best known for its role in DNA end resection to initiate DNA double-strand
break repair by homologous recombination. Recently, CtIP has also been shown to protect …
break repair by homologous recombination. Recently, CtIP has also been shown to protect …
DNA binding and bridging by human CtIP in the healthy and diseased states.
S De Bragança, F Balaguer-Pérez, S Northall… - Nucleic Acids …, 2024 - europepmc.org
The human DNA repair factor CtIP helps to initiate the resection of double-stranded DNA
breaks for repair by homologous recombination, in part through its ability to bind and bridge …
breaks for repair by homologous recombination, in part through its ability to bind and bridge …
Characterization, Manipulation, and Isolation of Paramecium aurelia Using a Micro‐Electromigration Chip and Computer Vision
AP Shunmugam, JG Fernandez - Advanced Materials …, 2020 - Wiley Online Library
Manipulating microorganisms with inherent motility is a challenging yet significant aim with
implications in many biological, environmental, and technological applications. Many …
implications in many biological, environmental, and technological applications. Many …