Pharmacological modulation of Nrf2/HO-1 signaling pathway as a therapeutic target of Parkinson's disease
Y Wang, L Gao, J Chen, Q Li, L Huo, Y Wang… - Frontiers in …, 2021 - frontiersin.org
Parkinson's disease (PD) is a complex neurodegenerative disorder featuring both motor and
nonmotor symptoms associated with a progressive loss of dopaminergic neurons in the …
nonmotor symptoms associated with a progressive loss of dopaminergic neurons in the …
Modulation of neurotrophic signaling pathways by polyphenols
Polyphenols are an important class of phytochemicals, and several lines of evidence have
demonstrated their beneficial effects in the context of a number of pathologies including …
demonstrated their beneficial effects in the context of a number of pathologies including …
Microglia mediated neuroinflammation: focus on PI3K modulation
Immune activation in the central nervous system involves mostly microglia in response to
pathogen invasion or tissue damage, which react, promoting a self-limiting inflammatory …
pathogen invasion or tissue damage, which react, promoting a self-limiting inflammatory …
bFGF protects against blood-brain barrier damage through junction protein regulation via PI3K-Akt-Rac1 pathway following traumatic brain injury
ZG Wang, Y Cheng, XC Yu, LB Ye, QH Xia… - Molecular …, 2016 - Springer
Many traumatic brain injury (TBI) survivors sustain neurological disability and cognitive
impairments due to the lack of defined therapies to reduce TBI-induced blood-brain barrier …
impairments due to the lack of defined therapies to reduce TBI-induced blood-brain barrier …
[HTML][HTML] Neuroprotective mechanisms of puerarin in central nervous system diseases: Update
CC Yu, YJ Du, J Li, Y Li, L Wang, LH Kong… - Aging and …, 2022 - ncbi.nlm.nih.gov
Due to global population aging and modern lifestyle changes, the incidence of central
nervous system (CNS) disorders, such as neurodegenerative diseases, neuropsychiatric …
nervous system (CNS) disorders, such as neurodegenerative diseases, neuropsychiatric …
Puerarin protects against high‐fat high‐sucrose diet‐induced non‐alcoholic fatty liver disease by modulating PARP‐1/PI3K/AKT signaling pathway and facilitating …
S Wang, FJ Yang, LC Shang, YH Zhang… - Phytotherapy …, 2019 - Wiley Online Library
As yet, there was no effective pharmacological therapy approved for non‐alcoholic fatty liver
disease (NAFLD). Here, we aimed to evaluate the therapeutic potential of puerarin against …
disease (NAFLD). Here, we aimed to evaluate the therapeutic potential of puerarin against …
Puerarin suppresses MPP+/MPTP-induced oxidative stress through an Nrf2-dependent mechanism
X Li, J Zhang, X Zhang, M Dong - Food and Chemical Toxicology, 2020 - Elsevier
In this study, we hypothesized that anti-parkinsonian effect of puerarin is attributable to its
antioxidant properties via Nrf2-dependent glutathione (GSH) biosynthesis mechanism …
antioxidant properties via Nrf2-dependent glutathione (GSH) biosynthesis mechanism …
Puerarin suppresses inflammation and ECM degradation through Nrf2/HO-1 axis in chondrocytes and alleviates pain symptom in osteoarthritic mice
X Chen, C Huang, H Sun, H Hong, J Jin, C Bei, Z Lu… - Food & Function, 2021 - pubs.rsc.org
Osteoarthritis (OA) is the most common degenerative joint disorder with no effective drugs.
Puerarin is a dietary supplement that has wide-ranging pharmacological effects. This study …
Puerarin is a dietary supplement that has wide-ranging pharmacological effects. This study …
Protective effects and mechanism of puerarin targeting PI3K/Akt signal pathway on neurological diseases
Q Wang, ZN Shen, SJ Zhang, Y Sun… - Frontiers in …, 2022 - frontiersin.org
Neurological diseases impose a tremendous and increasing burden on global health, and
there is currently no curative agent. Puerarin, a natural isoflavone extracted from the dried …
there is currently no curative agent. Puerarin, a natural isoflavone extracted from the dried …
Chemical Constituents from Hericium erinaceus Promote Neuronal Survival and Potentiate Neurite Outgrowth via the TrkA/Erk1/2 Pathway
CC Zhang, CY Cao, M Kubo, K Harada, XT Yan… - International journal of …, 2017 - mdpi.com
Hericium erinaceus is a culinary-medicinal mushroom used traditionally in Eastern Asia to
improve memory. In this work, we investigated the neuroprotective and neuritogenic effects …
improve memory. In this work, we investigated the neuroprotective and neuritogenic effects …