Mitochondrial pyruvate transport: a historical perspective and future research directions
KS McCommis, BN Finck - Biochemical journal, 2015 - portlandpress.com
Pyruvate is the end-product of glycolysis, a major substrate for oxidative metabolism, and a
branching point for glucose, lactate, fatty acid and amino acid synthesis. The mitochondrial …
branching point for glucose, lactate, fatty acid and amino acid synthesis. The mitochondrial …
The mitochondrial pyruvate carrier at the crossroads of intermediary metabolism
Pyruvate metabolism, a central nexus of carbon homeostasis, is an evolutionarily conserved
process and aberrant pyruvate metabolism is associated with and contributes to numerous …
process and aberrant pyruvate metabolism is associated with and contributes to numerous …
[HTML][HTML] Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport
Alternative modes of metabolism enable cells to resist metabolic stress. Inhibiting these
compensatory pathways may produce synthetic lethality. We previously demonstrated that …
compensatory pathways may produce synthetic lethality. We previously demonstrated that …
[HTML][HTML] Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye
MA Kanow, MM Giarmarco, CSR Jankowski… - elife, 2017 - elifesciences.org
Here we report multiple lines of evidence for a comprehensive model of energy metabolism
in the vertebrate eye. Metabolic flux, locations of key enzymes, and our finding that glucose …
in the vertebrate eye. Metabolic flux, locations of key enzymes, and our finding that glucose …
A glycolytic shift in Schwann cells supports injured axons
Axon degeneration is a hallmark of many neurodegenerative disorders. The current
assumption is that the decision of injured axons to degenerate is cell-autonomously …
assumption is that the decision of injured axons to degenerate is cell-autonomously …
Glymphatic clearance controls state-dependent changes in brain lactate concentration
I Lundgaard, ML Lu, E Yang, W Peng… - Journal of Cerebral …, 2017 - journals.sagepub.com
Brain lactate concentration is higher during wakefulness than in sleep. However, it is
unknown why arousal is linked to an increase in brain lactate and why lactate declines …
unknown why arousal is linked to an increase in brain lactate and why lactate declines …
[HTML][HTML] Regulation of substrate utilization by the mitochondrial pyruvate carrier
Pyruvate lies at a central biochemical node connecting carbohydrate, amino acid, and fatty
acid metabolism, and the regulation of pyruvate flux into mitochondria represents a critical …
acid metabolism, and the regulation of pyruvate flux into mitochondria represents a critical …
Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer
The mechanisms by which mitochondrial metabolism supports cancer anabolism remain
unclear. Here, we found that genetic and pharmacological inactivation of pyruvate …
unclear. Here, we found that genetic and pharmacological inactivation of pyruvate …
[HTML][HTML] Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects
Lactate exchange between glycolytic and oxidative cancer cells is proposed to optimize
tumor growth. Blocking lactate uptake through monocarboxylate transporter 1 (MCT1) …
tumor growth. Blocking lactate uptake through monocarboxylate transporter 1 (MCT1) …
[HTML][HTML] Loss of mitochondrial pyruvate carrier 2 in the liver leads to defects in gluconeogenesis and compensation via pyruvate-alanine cycling
KS McCommis, Z Chen, X Fu, WG McDonald, JR Colca… - Cell metabolism, 2015 - cell.com
Pyruvate transport across the inner mitochondrial membrane is believed to be a prerequisite
for gluconeogenesis in hepatocytes, which is important for the maintenance of …
for gluconeogenesis in hepatocytes, which is important for the maintenance of …