Pyruvate is the end-product of glycolysis, a major substrate for oxidative metabolism, and a
branching point for glucose, lactate, fatty acid and amino acid synthesis. The mitochondrial …

Pyruvate metabolism, a central nexus of carbon homeostasis, is an evolutionarily conserved
process and aberrant pyruvate metabolism is associated with and contributes to numerous …

Alternative modes of metabolism enable cells to resist metabolic stress. Inhibiting these
compensatory pathways may produce synthetic lethality. We previously demonstrated that …

Here we report multiple lines of evidence for a comprehensive model of energy metabolism
in the vertebrate eye. Metabolic flux, locations of key enzymes, and our finding that glucose …

Axon degeneration is a hallmark of many neurodegenerative disorders. The current
assumption is that the decision of injured axons to degenerate is cell-autonomously …

Brain lactate concentration is higher during wakefulness than in sleep. However, it is
unknown why arousal is linked to an increase in brain lactate and why lactate declines …

Pyruvate lies at a central biochemical node connecting carbohydrate, amino acid, and fatty
acid metabolism, and the regulation of pyruvate flux into mitochondria represents a critical …

The mechanisms by which mitochondrial metabolism supports cancer anabolism remain
unclear. Here, we found that genetic and pharmacological inactivation of pyruvate …

Lactate exchange between glycolytic and oxidative cancer cells is proposed to optimize
tumor growth. Blocking lactate uptake through monocarboxylate transporter 1 (MCT1) …

Pyruvate transport across the inner mitochondrial membrane is believed to be a prerequisite
for gluconeogenesis in hepatocytes, which is important for the maintenance of …