Caveolin-1 in the regulation of cell metabolism: a cancer perspective

ZC Nwosu, MP Ebert, S Dooley, C Meyer - Molecular cancer, 2016 - Springer
Abstract Caveolin-1 (CAV1) is an oncogenic membrane protein associated with endocytosis,
extracellular matrix organisation, cholesterol distribution, cell migration and signaling …

Caveolin-1 in oncogenic transformation, cancer, and metastasis

TM Williams, MP Lisanti - American Journal of Physiology …, 2005 - journals.physiology.org
Caveolae are 50-to 100-nm omega-shaped invaginations of the plasma membrane that
function as regulators of signal transduction. Caveolins are a class of oligomeric structural …

Caveolin-1 and cancer metabolism in the tumor microenvironment: markers, models, and mechanisms

F Sotgia, UE Martinez-Outschoorn… - Annual Review of …, 2012 - annualreviews.org
Caveolins are a family of membrane-bound scaffolding proteins that compartmentalize and
negatively regulate signal transduction. Recent studies have implicated a loss of caveolin-1 …

The myc oncogene: MarvelouslY complex

SK Oster, CSW Ho, EL Soucie, LZ Penn - 2002 - Elsevier
The activated product of the myc oncogene deregulates both cell growth and death check
points and, in a permissive environment, rapidly accelerates the affected clone through the …

Caveolin-1 in tumor progression: the good, the bad and the ugly

JG Goetz, P Lajoie, SM Wiseman, IR Nabi - Cancer and metastasis reviews, 2008 - Springer
Abstract Caveolin-1 (Cav1) is a multifunctional scaffolding protein with multiple binding
partners that is associated with cell surface caveolae and the regulation of lipid raft domains …

Caveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor gene

K Wiechen, L Diatchenko, A Agoulnik… - The American journal of …, 2001 - Elsevier
To identify novel markers differentially expressed in ovarian cancer versus normal ovary, we
hybridized microarrays with cDNAs derived from normal human ovaries and advanced stage …

Caveolae: mining little caves for new cancer targets

LA Carver, JE Schnitzer - Nature Reviews Cancer, 2003 - nature.com
Caveolae exist at cell surfaces as caveolin-coated invaginations that perform transport and
signalling functions influencing cell growth, apoptosis, angiogenesis and transvascular …

Caveolin-1 Maintains Activated Akt in Prostate CancerCells through Scaffolding Domain Binding Site Interactions with andInhibition of Serine/Threonine Protein …

L Li, CH Ren, SA Tahir, C Ren… - Molecular and cellular …, 2003 - Am Soc Microbiol
Previously it has been reported that caveolin-1 (cav-1) has antiapoptotic activities in prostate
cancer cells and functions downstream of androgenic stimulation. In this study, we …

Caveolin-1 inhibits anchorage-independent growth, anoikis and invasiveness in MCF-7 human breast cancer cells

G Fiucci, D Ravid, R Reich, M Liscovitch - Oncogene, 2002 - nature.com
Caveolin-1 is an essential structural constituent of caveolae that has been implicated in
mitogenic signaling and oncogenesis. Caveolin-1 is down-regulated in oncogene …

Betulinic acid suppresses breast cancer aerobic glycolysis via caveolin-1/NF-κB/c-Myc pathway

L Jiao, S Wang, Y Zheng, N Wang, B Yang… - Biochemical …, 2019 - Elsevier
Emerging evidence has suggested that targeting glycolysis may be a promising strategy for
cancer treatment. Betulinic acid (BA) is a natural pentacyclic terpene that has been reported …