The Escherichia coli stringent response, mediated by the alarmone ppGpp, is responsible
for the reorganization of cellular transcription upon nutritional starvation and other stresses …

In every organism, translation of the genetic information into functional proteins is performed
on the ribosome. In Escherichia coli up to 40% of the cell's total energy turnover is …

AtNOS1 was previously identified as a potential nitric-oxide synthase (NOS) in Arabidopsis
thaliana, despite lack of sequence similarity to animal NOSs. Although the dwarf and …

The presence of a distinct nucleus, the compartment for confining the genome, transcription
and RNA maturation, is a central (and eponymous) feature that distinguishes eukaryotes …

The assembly of the ribosome, a complex molecular machine composed of RNA and
protein, is a poorly understood process. Recent work has demonstrated that GTPases are …

In eukaryotes, nuclear export of the large (60S) ribosomal subunit requires the adapter
protein Nmd3p to provide the nuclear export signal. Here, we show that in yeast release of …

There is no doubt that the existing arsenal of antimicrobial agents we have in hand for the
treatment of infectious diseases is insufficient to protect us over the long term. 1-3 The …

Staphylococcus aureus produces biofilm and this mode of colonization facilitates infections
that are often difficult to treat and engender high morbidity and mortality. We have exploited …

Recent work has identified a subset of cells resident in tumors that exhibit properties similar
to those found in normal stem cells. Such cells are highly tumorigenic and may be involved …

Nucleostemin (NS) is a putative GTPase expressed preferentially in the nucleoli of neuronal
and embryonic stem cells and several cancer cell lines. Transfection and knockdown studies …