Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that acts on multiple cell
lineages, including dendritic cells, T cells, B cells, neutrophils, mast cells, eosinophils and …

Skin barrier dysfunction, a defining feature of atopic dermatitis (AD), arises from multiple
interacting systems. In AD, skin inflammation is caused by host–environment interactions …

Decades of work have elucidated cytokine signalling and transcriptional pathways that
control T cell differentiation and have led the way to targeted biologic therapies that are …

Many consider food allergy as the" second wave" of the allergy epidemic following the" first
wave" of respiratory allergy, ie, asthma and allergic rhinitis, plaguing westernized countries …

Background Atopic dermatitis is the most common chronic inflammatory skin disorder,
affecting up to 20% of children and 10% of adults in industrialized countries. This highly …

Atopic dermatitis is a common, chronic inflammatory skin disease that is characterized by
skin barrier dysfunction, inflammation and intense itch. Although the exact mechanisms …

Obesity is a major risk factor for psoriasis, but how obesity disrupts the regulatory
mechanisms that keep skin inflammation in check is unclear. Here, we found that skin was …

The cytokine TSLP has been shown to be a key factor in maintaining immune homeostasis
and regulating inflammatory responses at mucosal barriers. While the role of TSLP in type 2 …

The gut-associated lymphoid tissue (GALT) faces a considerable challenge. It encounters
antigens derived from an estimated 1014 commensal microbes and greater than 30 kg of …

Basophils are the rarest granulocytes and have long been overlooked in immunological
research due to their rarity and similarities with tissue-resident mast cells. In the last two …