Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies
Cardiac hypertrophy can be defined as an increase in heart mass. Pathological cardiac
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …
[HTML][HTML] The genetic basis of exercise and cardiorespiratory fitness–relation to cardiovascular disease
M Klevjer, AN Nordeidet, A Bye - Current Opinion in Physiology, 2023 - Elsevier
Endurance training is associated with increased cardiorespiratory fitness (CRF) and
decreased risk of cardiovascular disease (CVD). However, a causal relationship between …
decreased risk of cardiovascular disease (CVD). However, a causal relationship between …
Myocardial autophagy activation and suppressed survival signaling is associated with insulin resistance in fructose-fed mice
Fructose intake is linked with the increasing prevalence of insulin resistance and there is
now evidence for a specific insulin-resistant cardiomyopathy. The aim of this study was to …
now evidence for a specific insulin-resistant cardiomyopathy. The aim of this study was to …
[HTML][HTML] The endocrinological component and signaling pathways associated to cardiac hypertrophy
APC Takano, N Senger… - Molecular and cellular …, 2020 - Elsevier
Although myocardial growth corresponds to an adaptive response to maintain cardiac
contractile function, the cardiac hypertrophy is a condition that occurs in many …
contractile function, the cardiac hypertrophy is a condition that occurs in many …
Phosphatidylinositol-3-kinase p110γ contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells
S Hohenester, A Gates, R Wimmer, U Beuers… - Journal of …, 2010 - Elsevier
BACKGROUND & AIMS: Glycochenodeoxycholate (GCDC) and taurolithocholate (TLC) are
hepatotoxic and cholestatic bile salts, whereas tauroursodeoxycholate (TUDC) is …
hepatotoxic and cholestatic bile salts, whereas tauroursodeoxycholate (TUDC) is …
Insights into the activation and inhibition of angiotensin II type 1 receptor in the mechanically loaded heart
J Wu, J You, S Wang, L Zhang, H Gong, Y Zou - Circulation Journal, 2014 - jstage.jst.go.jp
1284 WU J et al. tion after stretch. Coincidently, we observed that a neutralizing antibody of
AngII abolished the AngII-but not stretch-induced activation of extracellular signal-regulated …
AngII abolished the AngII-but not stretch-induced activation of extracellular signal-regulated …
Role of PI3Kα and sarcolemmal ATP-sensitive potassium channels in epoxyeicosatrienoic acid mediated cardioprotection
SN Batchu, KR Chaudhary, H El-Sikhry, W Yang… - Journal of molecular and …, 2012 - Elsevier
AIMS: Epoxyeicosatrienoic acids (EETs) are cytochrome P450 epoxygenase metabolites of
arachidonic acid that have known cardioprotective properties. While the mechanism (s) …
arachidonic acid that have known cardioprotective properties. While the mechanism (s) …
Genome-Wide association study identifies new genetic determinants of cardiorespiratory fitness: the trøndelag health study
M Klevjer, AN Nordeidet, AF Hansen, E Madssen… - 2022 - ntnuopen.ntnu.no
Purpose Low cardiorespiratory fitness (CRF) is a major risk factor for cardiovascular disease
(CVD) and a stronger predictor of CVD morbidity and mortality than established risk factors …
(CVD) and a stronger predictor of CVD morbidity and mortality than established risk factors …
[HTML][HTML] Intracellular signaling by bile acids
MS Anwer - Journal of bio-science, 2012 - ncbi.nlm.nih.gov
Bile acids, synthesized from cholesterol, are known to produce beneficial as well as toxic
effects in the liver. The beneficial effects include choleresis, immunomodulation, cell …
effects in the liver. The beneficial effects include choleresis, immunomodulation, cell …
[HTML][HTML] Possible biomarkers for the early detection of HIV-associated heart diseases: a proteomics and bioinformatics prediction
The frequency of cardiovascular disorders is increasing in HIV-infected individuals despite a
significant reduction in the viral load by antiretroviral therapies (ART). Since the CD4+ T …
significant reduction in the viral load by antiretroviral therapies (ART). Since the CD4+ T …