The atherogenic role of circulating modified lipids in atherosclerosis

VI Summerhill, AV Grechko, SF Yet, IA Sobenin… - International journal of …, 2019 - mdpi.com
Lipid accumulation in the arterial wall is a crucial event in the development of atherosclerotic
lesions. Circulating low-density lipoprotein (LDL) is the major source of lipids that …

Vitamin C: basic metabolism and its function as an index of oxidative stress

S Kojo - Current medicinal chemistry, 2004 - ingentaconnect.com
Vitamin C (ASC) is well known as an outstanding antioxidant in animal tissues. This concept
is reviewed from a chemical standpoint, starting from a chemical view of radical reactions in …

Immunohistochemical demonstration of enzymatically modified human LDL and its colocalization with the terminal complement complex in the early atherosclerotic …

M Torzewski, M Klouche, J Hock… - … , and vascular biology, 1998 - Am Heart Assoc
Treatment of low density lipoprotein (LDL) with degrading enzymes transforms the molecule
to a moiety that is micromorphologically indistinguishable from lipoproteinaceous particles …

Impact of protein glycosylation on lipoprotein metabolism and atherosclerosis

A Pirillo, M Svecla, AL Catapano… - Cardiovascular …, 2021 - academic.oup.com
Protein glycosylation is a post-translational modification consisting in the enzymatic
attachment of carbohydrate chains to specific residues of the protein sequence. Several …

Modified low density lipoprotein and lipoprotein-containing circulating immune complexes as diagnostic and prognostic biomarkers of atherosclerosis and type 1 …

AN Orekhov, YV Bobryshev, IA Sobenin… - International journal of …, 2014 - mdpi.com
In atherosclerosis; blood low-density lipoproteins (LDL) are subjected to multiple enzymatic
and non-enzymatic modifications that increase their atherogenicity and induce …

Role of oxidized low density lipoprotein in atherogenesis

S Parthasarathy, SM Rankin - Progress in lipid research, 1992 - Elsevier
Atherosclerosis is a disease that affects large arteries. The early atherosclerotic lesion, the
fatty streak, is characterized by the build up of lipids in the intima. These lipids are derived …

LDL-is a lipid hydroperoxide-enriched circulating lipoprotein

A Sevanian, G Bittolo-Bon, G Cazzolato, H Hodis… - Journal of lipid …, 1997 - Elsevier
A subclass of LDL described on the basis of its greater electronegativity and oxidative status
is further characterized using a new, highly sensitive single photon counting technique to …

Mannan binding lectin as an adjunct to risk assessment for myocardial infarction in individuals with enhanced risk

S Saevarsdottir, OO Oskarsson, T Aspelund… - The Journal of …, 2005 - rupress.org
Inflammation can predispose to myocardial infarction (MI), and mannan binding lectin (MBL)
promotes phagocytic clearance of inflammatory agents, but the predictive value of MBL …

Human plasma trans-sialidase causes atherogenic modification of low density lipoprotein

VV Tertov, VV Kaplun, IA Sobenin, EY Boytsova… - Atherosclerosis, 2001 - Elsevier
In earlier studies we have found that incubation of low density lipoprotein (LDL) with
autologous blood plasma-derived serum leads to a loss of sialic acid from lipoprotein …

[HTML][HTML] Low density lipoprotein-containing circulating immune complexes: role in atherosclerosis and diagnostic value

IA Sobenin, JT Salonen, AV Zhelankin… - BioMed Research …, 2014 - hindawi.com
It has been suggested that low density lipoprotein-containing circulating immune complexes
(LDL-CIC) play a role in atherogenesis and are involved in the formation of early …