The potential role of the orexin reward system in future treatments for opioid drug abuse
Despite a history of more than a century of intense research in drug addiction, with currently
available medication and behavioral therapy, the rate of relapse to drug use is 40–60 …
available medication and behavioral therapy, the rate of relapse to drug use is 40–60 …
The effect of stress and reward on encoding future fear memories
LE DiFazio, M Fanselow, MJ Sharpe - Behavioural brain research, 2022 - Elsevier
Prior experience changes the way we learn about our environment. Stress predisposes
individuals to developing psychological disorders, just as positive experiences protect from …
individuals to developing psychological disorders, just as positive experiences protect from …
Structural plasticity of dopaminergic neurons requires the activation of the D3R-nAChR heteromer and the PI3K-ERK1/2/Akt-induced expression of c-Fos and p70S6K …
V Mutti, F Bono, Z Tomasoni, L Bontempi… - Molecular …, 2022 - Springer
We have previously shown that the heteromer composed by the dopamine D3 receptor
(D3R) and the nicotinic acetylcholine receptor (nAChR)(D3R-nAChR heteromer) is …
(D3R) and the nicotinic acetylcholine receptor (nAChR)(D3R-nAChR heteromer) is …
Neuroplastic Correlates in the mPFC Underlying the Impairment of Stress‐Coping Ability and Cognitive Flexibility in Adult Rats Exposed to Chronic Mild Stress during …
Y Zhang, F Shao, Q Wang, X Xie, W Wang - Neural Plasticity, 2017 - Wiley Online Library
Using a valid chronic mild stress (CMS) model of depression, we found that adolescent
(postnatal days [PND] 28–41) CMS induced transient alterations in anhedonia that did not …
(postnatal days [PND] 28–41) CMS induced transient alterations in anhedonia that did not …
Motor skill learning and reward consumption differentially affect VTA activation
S Leemburg, T Canonica, A Luft - Scientific reports, 2018 - nature.com
Dopamine release from the ventral tegmental area (VTA) terminals in the primary motor
cortex (M1) enables motor skill acquisition. Here, we test the hypothesis that dopaminergic …
cortex (M1) enables motor skill acquisition. Here, we test the hypothesis that dopaminergic …
Changes in the levels of p-ERK, p-CREB, and c-fos in rat mesocorticolimbic dopaminergic system after morphine-induced conditioned place preference: the role of …
ERK pathway plays a critical role in the cellular adaptive responses to environmental
changes. Stressful conditions can induce the activation of activate ERK, and its downstream …
changes. Stressful conditions can induce the activation of activate ERK, and its downstream …
Intrahippocampal administration of D2 but not D1 dopamine receptor antagonist suppresses the expression of conditioned place preference induced by morphine in …
A Haghparast, MH Esmaeili, Z Taslimi, M Kermani… - Neuroscience …, 2013 - Elsevier
The ventral tegmental area (VTA) as a major source of dopamine neurons projecting to
cortical and limbic regions has a crucial role in reward and addiction. The current study …
cortical and limbic regions has a crucial role in reward and addiction. The current study …
Sinomenine protects against morphine dependence through the NMDAR1/CAMKII/CREB pathway: a possible role of astrocyte-derived exosomes
J Ou, Y Zhou, C Li, Z Chen, H Li, M Fang, C Zhu, C Huo… - Molecules, 2018 - mdpi.com
Sinomenine is a nonaddictive alkaloid used to prevent morphine dependence, even
thoughits mechanism isnot fully understood. Astrocytes aggravate the pathological process …
thoughits mechanism isnot fully understood. Astrocytes aggravate the pathological process …
Role of orexinergic receptors in the dentate gyrus of the hippocampus in the acquisition and expression of morphine-induced conditioned place preference in rats
Orexinergic projections derived from the lateral hypothalamus (LH) play a crucial role in the
acquisition and expression of morphine-conditioned place preference (CPP). It has been …
acquisition and expression of morphine-conditioned place preference (CPP). It has been …
Role of dopamine D1-like receptor within the nucleus accumbens in acute food deprivation-and drug priming-induced reinstatement of morphine seeking in rats
F Sadeghzadeh, V Babapour, A Haghparast - Behavioural brain research, 2015 - Elsevier
Dopamine is a predominant neurotransmitter in the nervous system, which plays an
important role in both drug priming-and cue-induced reinstatement of cocaine and heroin …
important role in both drug priming-and cue-induced reinstatement of cocaine and heroin …