Histone deacetylases (HDACs) play a key role in homeostasis of protein acetylation in
histones and other proteins and in regulating fundamental cellular activities such as …

Histone deacetylase enzymes, which have been divided into three distinct structural classes,
operate by zinc-dependent (class I/II) or NAD-dependent (class III) mechanisms. Class I/II …

Although protein phosphorylation has been characterized more extensively, modulation of
the acetylation state of signaling molecules is now being recognized as a key means of …

Parkinson's disease (PD) is the most common movement disorder affecting more than 4
million people worldwide. The primary motor symptoms of the disease are due to …

Growing evidence from in vitro studies supports that valproic acid (VPA), an anti‐convulsant
and mood‐stabilizing drug, has neuroprotective effects. The present study investigated …

Parkinson's disease (PD) is characterized by the selective and progressive loss of
dopaminergic (DA) neurons in the midbrain substantia nigra. Currently, available treatment …

Manic-depressive illness has been conceptualized as a neurochemical illness. However,
brain imaging and postmortem studies reveal gray-matter reductions, as well as neuronal …

Recent studies have shown that sodium butyrate and other short‐chain fatty acids (SCFAs)
can prevent inflammation in colon diseases. Our aim was to elucidate whether sodium …

Valproic acid (VPA, 2-propylpentanoic acid) has been widely used as an antiepileptic drug
and for the therapy of bipolar disorders for several years. Its mechanism of action was …

Valproic acid (VPA), a widely prescribed drug for seizures and bipolar disorder, has been
shown to be an inhibitor of histone deacetylase (HDAC). Our previous study has …