Cells respond to changes in the physical and chemical properties of the environment. These
changes include alterations in the amount of nutrients, growth factors, cytokines, and …

The c-Jun NH2-terminal kinase (JNK) is a member of an evolutionarily conserved sub-family
of mitogen-activated protein (MAP) kinases. Recent studies have led to progress towards …

To identify genetic susceptibility loci for nasopharyngeal carcinoma (NPC), a genome-wide
association study was performed using 464,328 autosomal SNPs in 1,583 NPC affected …

Members of the Prdm family are characterized by an N-terminal PR domain that is related to
the SET methyltransferase domain, and multiple zinc fingers that mediate sequence-specific …

Evi-1 has been recognized as one of the dominant oncogenes associated with murine and
human myeloid leukemia. Here, we show that hematopoietic stem cells (HSCs) in Evi-1 …

The PRDM family has recently spawned considerable interest as it has been implicated in
fundamental aspects of cellular differentiation and exhibits expanding ties to human …

Evi-1 is a zinc finger nuclear protein whose inappropriate expression leads to leukemic
transformation of hematopoietic cells in mice and humans. This was previously shown to …

The molecular regulation of human hematopoietic stem cell (HSC) maintenance is
therapeutically important, but limitations in experimental systems and interspecies variation …

Evi1 (ecotropic viral integration site 1) is essential for proliferation of hematopoietic stem
cells and implicated in the development of myeloid disorders. Particularly, high Evi1 …

The PR/SET domain family (PRDM) comprise a family of genes whose protein products
share a conserved N-terminal PR [PRDI-BF1 (positive regulatory domain I-binding factor 1) …