Testicular cancer is the most common malignancy among men between 14 and 44 years of
age, and its incidence has risen over the past two decades in Western countries. Both …

Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …

Germ-cell tumours (GCTs) affect predominantly younger males aged between 15 and 40
years, with nearly 74 500 new cases estimated globally in 2020. 1 About one-third of all GCT …

We studied 137 primary testicular germ cell tumors (TGCTs) using high-dimensional assays
of genomic, epigenomic, transcriptomic, and proteomic features. These tumors exhibited …

Human germ cell tumours (GCTs) are derived from stem cells of the early embryo and the
germ line. They occur in the gonads (ovaries and testes) and also in extragonadal sites …

Somatic copy number variations (CNV) may drive cancer progression through both coding
and noncoding transcripts. However, noncoding transcripts resulting from CNV are largely …

Expression quantitative trait loci (eQTLs) studies provide associations of genetic variants
with gene expression but fall short of pinpointing functionally important eQTLs. Here, using …

Testicular tumors are the most common tumors in adolescent and young men and germ cell
tumors (TGCTs) account for most of all testicular cancers. Increasing incidence of TGCTs …

Current (high throughput omics-based) data support the model that human (malignant) germ
cell tumors are not initiated by somatic mutations, but, instead through a defined locked …

Genome-wide association studies (GWAS) have led to the identification of hundreds of
susceptibility loci across cancers, but the impact of further studies remains uncertain. Here …