Our concepts of sound localization in the vertebrate brain are widely based on the general
assumption that both the ability to detect air-borne sounds and the neuronal processing are …

The OTOF gene encodes otoferlin, a critical protein at the synapse of auditory sensory cells,
the inner hair cells (IHCs). In the absence of otoferlin, signal transmission of IHCs fails due to …

Perceptual abnormalities such as hyperacusis and tinnitus often occur after acoustic
overexposure. Although such exposure can also result in permanent threshold elevation …

Early binaural experience can recalibrate central auditory circuits that support spatial
hearing. However, it is not known how binaural integration matures shortly after hearing …

Age-related hearing loss is a very common sensory disability, affecting one in three older
adults. Establishing a link between anatomical, physiological, and behavioral markers of …

The multi‐C2 domain protein otoferlin is required for hearing and mutated in human
deafness. Some OTOF mutations cause a mild elevation of auditory thresholds but strong …

Noise-induced hearing loss generally induces loudness recruitment, but sometimes gives
rise to hyperacusis, a debilitating condition in which moderate intensity sounds are …

Acoustic startle response (ASR) modification procedures, especially prepulse inhibition
(PPI), are increasingly used as behavioral measures of auditory processing and …

The etiology of tinnitus is known to be diverse in the human population. An appropriate
animal model of tinnitus should incorporate this pathological diversity. Previous studies …

When faced with sensory stimuli, an organism may be required to detect very small
differences in a physical parameter (discrimination), while in other situations it may have to …