The targeting of vascular endothelial growth factor A (VEGFA), a crucial regulator of both
normal and pathological angiogenesis, has revealed innovative therapeutic approaches in …

There are two major types of ocular neovascularization that affect the retina, retinal
neovascularization (NV) and subretinal or choroidal NV. Retinal NV occurs in a group of …

Biology of Vascular Endothelial Growth Factor | Endocrine Reviews | Oxford Academic Skip to
Main Content Advertisement Oxford Academic Journals Books Search Menu Information …

Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen in vitro and
an angiogenic inducer in a variety of in vivo models. Hypoxia has been shown to be a major …

Background Pegaptanib, an anti–vascular endothelial growth factor therapy, was evaluated
in the treatment of neovascular age-related macular degeneration. Methods We conducted …

Данное, второе, издание книги значительно переработано с учетом современных
представлений о патогенезе, диагностике и лечении глаукомы. В книге рассмотрены …

Aptamers are oligonucleotide ligands that are selected for high-affinity binding to molecular
targets. Pegaptanib sodium (Macugen; Eyetech Pharmaceuticals/Pfizer) is an RNA aptamer …

Neovascular glaucoma (NVG) is a sight-threatening secondary glaucoma characterized by
appearance of new vessels over the iris and proliferation of fibrovascular tissue in the …

The vascular beds supplying the retina may sustain injury as a result of underlying disease
such as diabetes, and/or the interaction of genetic predisposition, environmental insults, and …

The growth of human tumors and development of metastases depend on the de novo
formation of blood vessels. The formation of new blood vessels is tightly regulated by …