Inwardly rectifying K+ (Kir) channels allow K+ to move more easily into rather than out of the
cell. They have diverse physiological functions depending on their type and their location …

G protein-gated inwardly rectifying potassium (GIRK) channels hyperpolarize neurons in
response to activation of many different G protein-coupled receptors and thus control the …

Steroid hormones can act as chemical messengers in a wide range of species and target
tissues to produce both slow genomic responses, and rapid non-genomic responses …

A long-standing goal in protein science and clinical genetics is to develop quantitative
models of sequence, structure, and function relationships to understand how mutations …

The Kir3. 1 K+ channel participates in heart rate control and neuronal excitability through G‐
protein and lipid signaling pathways. Expression in Escherichia coli has been achieved by …

Inwardly rectifying K+ (Kir) channels have a wide range of functions including the control of
neuronal signalling, heart rate, blood flow and insulin release. Because of the physiological …

Potassium channels have been studied intensively in terms of the relationship between
molecular structure and physiological function. They provide an opportunity to integrate …

Ethanol modifies neural activity in the brain by modulating ion channels. Ethanol activates G
protein–gated inwardly rectifying K+ channels, but the molecular mechanism is not well …

Ion channels are end-targets (effectors) in a large number of regulatory pathways that are
initiated by G-protein-coupled neurotransmitters and hormones. Modulation of ion channels …

Members of the K2P potassium channel family regulate neuronal excitability and are
implicated in pain, anaesthetic responses, thermosensation, neuroprotection, and mood …