An expanding number of metabolite-binding riboswitch classes are being discovered in the
noncoding portions of bacterial genomes. Findings over the last decade indicate that …

Riboswitches are gene control elements that directly bind to specific ligands to regulate
gene expression without the need for proteins. They are found in all three domains of life …

Riboswitches are commonly used by bacteria to detect a variety of metabolites and ions to
regulate gene expression. To date, nearly 40 different classes of riboswitches have been …

Cyclic di-adenosine monophosphate (c-di-AMP) is a recently discovered bacterial second
messenger implicated in the control of cell wall metabolism, osmotic stress responses and …

The guanidyl moiety is a component of fundamental metabolites, including the amino acid
arginine, the energy carrier creatine, and the nucleobase guanine. Curiously, reports …

The highly structured, cis-encoded RNA elements known as riboswitches modify gene
expression upon binding a wide range of molecules. The yybP-ykoY motif was one of the …

Riboswitches are noncoding portions of certain mRNAs that bind metabolite, coenzyme,
signaling molecule, or inorganic ion ligands and regulate gene expression. Most known …

Gene regulation in cis by riboswitches is prevalent in bacteria. The yybP-ykoY riboswitch
family is quite widespread, yet its ligand and function remained unknown. Here, we …

Summary Over 30 years ago, ZTP (5-aminoimidazole-4-carboxamide riboside 5′-
triphosphate), a modified purine biosynthetic intermediate, was proposed to signal 10-formyl …

Gene control systems sometimes interpret multiple signals to set the expression levels of the
genes they regulate. In rare instances, ligand-binding riboswitch aptamers form tandem …