The deeper understanding of non-coding RNAs has recently changed the dogma of
molecular biology assuming protein-coding genes as unique functional biological effectors …

Multiple myeloma (MM) drug resistance (DR) is a multistep transformation process based on
a powerful interplay between bone marrow stromal cells and MM cells that allows the latter …

ABSTRACT DNA methylation aberrancies are hallmarks of human cancers and are
characterized by global DNA hypomethylation of repetitive elements and non-CpG rich …

Epigenetic abnormalities are common in hematologic malignancies, including multiple
myeloma, and their effects can be efficiently counteracted by a class of tumor suppressor …

Heart failure creates a leading public health burden worldwide and cardiac fibrosis is a
hallmark of pathological cardiac remodeling which was found in HF patients. In this study …

Chromatin can adopt a decondensed state linked to gene transcription (euchromatin) and a
condensed state linked to transcriptional repression (heterochromatin). These states are …

Multiple myeloma (MM) is tightly dependent on inflammatory bone marrow
microenvironment. IL-17 producing CD4+ T cells (Th17) sustain MM cells growth and …

Abstract miR-21 is an oncogenic microRNA (miRNA) with an emerging role as therapeutic
target in human malignancies, including multiple myeloma (MM). Here we investigated …

Cancer is one of the leading causes of death worldwide and it can affect any part of the
organism. It arises as a consequence of the genetic and epigenetic changes that lead to the …

Olive oil contains different biologically active polyphenols, among which oleacein, the most
abundant secoiridoid, has recently emerged for its beneficial properties in various disease …