Biology and biomechanics of the heart valve extracellular matrix

KM Kodigepalli, K Thatcher, T West… - Journal of …, 2020 - mdpi.com
Heart valves are dynamic structures that, in the average human, open and close over
100,000 times per day, and 3× 109 times per lifetime to maintain unidirectional blood flow …

[HTML][HTML] Heart valve biomechanics and underlying mechanobiology

S Ayoub, G Ferrari, RC Gorman… - Comprehensive …, 2016 - ncbi.nlm.nih.gov
Heart valves control unidirectional blood flow within the heart during the cardiac cycle. They
have a remarkable ability to withstand the demanding mechanical environment of the heart …

Manifold learning based data-driven modeling for soft biological tissues

Q He, DW Laurence, CH Lee, JS Chen - Journal of biomechanics, 2021 - Elsevier
Data-driven modeling directly utilizes experimental data with machine learning techniques
to predict a material's response without the necessity of using phenomenological constitutive …

Simulation of the 3D hyperelastic behavior of ventricular myocardium using a finite-element based neural-network approach

W Zhang, DS Li, T Bui-Thanh, MS Sacks - Computer methods in applied …, 2022 - Elsevier
High-fidelity cardiac models using attribute-rich finite element based models have been
developed to a very mature stage. However, such finite-element based approaches remain …

[HTML][HTML] Mechanical behavior and collagen structure of degenerative mitral valve leaflets and a finite element model of primary mitral regurgitation

MJ Sadeghinia, HM Aguilera, S Urheim, RM Persson… - Acta Biomaterialia, 2023 - Elsevier
Degenerative mitral valve disease is the main cause of primary mitral regurgitation with two
phenotypes: fibroelastic deficiency (FED) often with localized myxomatous degeneration …

On the simulation of mitral valve function in health, disease, and treatment

MS Sacks, A Drach, CH Lee… - Journal of …, 2019 - asmedigitalcollection.asme.org
The mitral valve (MV) is the left atrioventricular heart valve that regulates blood flow between
the left atrium and left ventricle (LV) during the cardiac cycle. Contrary to the aortic valve …

A novel constitutive model for passive right ventricular myocardium: evidence for myofiber–collagen fiber mechanical coupling

R Avazmohammadi, MR Hill, MA Simon… - … and modeling in …, 2017 - Springer
The function of right ventricle (RV) is recognized to play a key role in the development of
many cardiopulmonary disorders, such as pulmonary arterial hypertension (PAH). Given the …

Calcific aortic valve disease is associated with layer-specific alterations in collagen architecture

HN Hutson, T Marohl, M Anderson, K Eliceiri… - PloS one, 2016 - journals.plos.org
Disorganization of the valve extracellular matrix (ECM) is a hallmark of calcific aortic valve
disease (CAVD). However, while microarchitectural features of the ECM can strongly …

Neural network approaches for soft biological tissue and organ simulations

MS Sacks, S Motiwale… - Journal of …, 2022 - asmedigitalcollection.asme.org
Given the functional complexities of soft tissues and organs, it is clear that computational
simulations are critical in their understanding and for the rational basis for the development …

Mechanics of the tricuspid valve—From clinical diagnosis/treatment, in-vivo and in-vitro investigations, to patient-specific biomechanical modeling

CH Lee, DW Laurence, CJ Ross, KE Kramer, AR Babu… - Bioengineering, 2019 - mdpi.com
Proper tricuspid valve (TV) function is essential to unidirectional blood flow through the right
side of the heart. Alterations to the tricuspid valvular components, such as the TV annulus …