The aging and elderly population are particularly susceptible to cardiovascular disease. Age
is an independent risk factor for cardiovascular disease (CVD) in adults, but these risks are …

Acute and chronic lung injuries are among the leading causes of mortality worldwide. Lung
injury can affect several components of the respiratory system, including the airways …

Oxygen administration is uniformly used in emergency and intensive care medicine and has
life-saving potential in critical conditions. However, excessive oxygenation also has …

Purpose Hyperoxia may induce pulmonary injury and may increase oxidative stress. In this
retrospective database study we aimed to evaluate the response to hyperoxia by intensivists …

Although oxygen (O2) is essential for aerobic life, it can also be an important source of
cellular damage. Supra-physiological levels of O2 determine toxicity due to exacerbated …

BACKGROUND: Optimal titration of inspired oxygen is important to prevent hyperoxia in
mechanically ventilated patients in ICUs. There is mounting evidence of the deleterious …

Background High inspiratory oxygen concentrations are frequently administered in
ventilated patients in the intensive care unit (ICU) but may induce lung injury and systemic …

Background. Preterm birth implies an array of respiratory diseases including apnea of
prematurity and bronchopulmonary dysplasia (BPD). Caffeine has been introduced to treat …

In this study our aim was to investigate the time courses of inflammation, oxidative stress and
tissue damage after hyperoxia in the mouse lung. Groups of BALB/c mice were exposed to …

Background Mechanical ventilation and hyperoxia have the potential to independently
promote lung injury and inflammation. Our purpose was to study both time-and dose …